LOINC Code 74034-0: MAML2 11q21 rearrangements FISH Doc (Tiss)

What is this code?

LOINC codes identify tests, measurements, observations, survey items, and clinical questions in a standardized way. It is associated with the component MAML2 11q21 gene rearrangements. It is commonly used with the system or sample type Tiss.

When is it used?

• Used in lab systems, EHRs, and clinical data exchange.
• May identify a test, observation, survey item, or clinical document request rather than a diagnosis.
• Status: ACTIVE
• Order vs observation: Both
• Method: FISH

What it does not mean

• The code identifies the observation or test, not the actual result.

Key facts

• MAML2 11q21 gene rearrangements in Tissue by FISH
• MAML2 11q21 gene rearrangements
• Rearrangements within the MAML2 gene located on chromosome 11q21 are detected in tissue (e.g. salivary gland tumors) by in-situ hybridization (e.g. FISH) methods. Presence of split signals indicate gene rearrangement. MAML2 rearrangements must be present in greater than or equal to 10% of lesional cells in order to be considered positive. The submitter's lab for this term report results (e.g. percent of lesional cells, ISCN nomenclature, and qualification of a positive result) as descriptive text. For example, a narrative result may state, "50% of lesional cells contain MAML2 rearrangement, nuc ish(MAML2x2)(5MAML2 sep 3MAML2x1)[100/200]. MAML2 rearrangement must be present in greater than or equal to 10% of lesional cells in order to be considered positive." Results are used to diagnose Mucoepidermoid carcinoma (MEC). Other carcinomas, such as salivary duct carcinoma, adenosquamous carcinoma, acinic cell carcinoma, and Warthin tumor are negative for the MAML2 rearrangements.
• Document; Finding; Findings; Fluorescent in situ hybridization; Genetics; Heredity; Heritable; Inherited; Molecular pathology; MOLPATH; MOLPATH.REARRANGEMENTS; Point in time; Random; Rearr; Rearrangement; Tissue; Tissue, unspecified

Where you may see this code

You may see this code in lab systems, lab reports, EHR exports, interoperability feeds, or other structured clinical data exchanges.

Common synonyms

Frequently asked questions