ICD10BillableValid for clinical use
ICD-10 Code B25.9: Cytomegaloviral disease, unspecified
Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026
What is this code?
ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Certain infectious and parasitic diseases (A00-B99).
đź“‹Clinical overview
This ICD-10 code is commonly used when documentation describes cytomegaloviral disease. The most accurate code depends on whether the chart identifies pneumonitis, hepatitis, pancreatitis, another specified CMV manifestation, or an unspecified cytomegaloviral presentation.
When is it used?
- May be used when a clinician documents cytomegaloviral disease, unspecified in a patient's medical record.
- May appear in hospital records, claims, referrals, and clinical documentation.
- This code can be used as a clinically usable diagnosis entry in standardized coding workflows.
What it does not mean
- A code alone does not explain severity, treatment plan, or outcome.
- A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
đź©şClinical context
When commonly used
- Infectious-disease, transplant, oncology, inpatient, pulmonary, gastroenterology, and follow-up documentation where CMV is part of the active assessment, especially in immunocompromised patients.
- Coding and utilization-review workflows where the chart identifies the affected organ system and that organ involvement changes final CMV code specificity.
Common management context
- Evaluation often includes viral-testing review, symptom assessment, organ-specific monitoring, imaging or lab review, antiviral-treatment planning, and specialist coordination when CMV causes clinically significant disease.
- Documentation usually becomes more specific when the chart identifies lung versus liver versus pancreatic involvement, or names another specified CMV manifestation rather than leaving the disease broad or unspecified.
- Specialist context already linked on this page includes Infectious Disease Specialist, General Physician.
🔍Key distinctions
Important notes
- This ICD-10 family captures clinically significant cytomegaloviral disease across multiple organ systems rather than a single anatomic site alone.
- Organ-system detail matters here, because pneumonitis, hepatitis, pancreatitis, and other specified CMV manifestations are coded separately when documented.
- This title preserves unspecified cytomegaloviral-disease detail; if the chart identifies the affected organ system more clearly, a more specific CMV code may be used.
- Documentation that describes cytomegaloviral disease is coded differently from herpes simplex infection, other viral hepatitis, bacterial pneumonia, or noninfectious organ inflammation because the CMV organism and affected organ system drive final code selection.
Related codes to consider
B25.0Cytomegaloviral pneumonitis
Related cytomegaloviral-disease ICD-10 code; documentation often becomes more specific when the chart identifies lung versus liver versus pancreatic involvement or another named CMV manifestation.
B25.1Cytomegaloviral hepatitis
Related cytomegaloviral-disease ICD-10 code; documentation often becomes more specific when the chart identifies lung versus liver versus pancreatic involvement or another named CMV manifestation.
B25.2Cytomegaloviral pancreatitis
Related cytomegaloviral-disease ICD-10 code; documentation often becomes more specific when the chart identifies lung versus liver versus pancreatic involvement or another named CMV manifestation.
B25.8Other cytomegaloviral diseases
Related cytomegaloviral-disease ICD-10 code; documentation often becomes more specific when the chart identifies lung versus liver versus pancreatic involvement or another named CMV manifestation.
Code hierarchy
chapter
1Certain infectious and parasitic diseases (A00-B99)
block
B25-B34Other viral diseases
category
B25Cytomegaloviral disease
currentB25
Where you may see this code
You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.
Related specialists
Infectious Disease SpecialistGeneral Physician
Related codes
Sibling codes
Coverage-related procedures and services
CPT 70460high
COMPUTED TOMOGRAPHY, HEAD OR BRAIN; WITH CONTRAST MATERIAL(S)
Source: CMS coverage guidance
CPT 70450high
COMPUTED TOMOGRAPHY, HEAD OR BRAIN; WITHOUT CONTRAST MATERIAL
Source: CMS coverage guidance
CPT 70470high
COMPUTED TOMOGRAPHY, HEAD OR BRAIN; WITHOUT CONTRAST MATERIAL, FOLLOWED BY CONTRAST MATERIAL(S) AND FURTHER SECTIONS
Source: CMS coverage guidance
HCPCS J1552high
INJECTION, IMMUNE GLOBULIN (ALYGLO), 500 MG
Source: CMS coverage guidance
HCPCS J1554high
INJECTION, IMMUNE GLOBULIN (ASCENIV), 500 MG
Source: CMS coverage guidance
HCPCS J1556high
INJECTION, IMMUNE GLOBULIN (BIVIGAM), 500 MG
Source: CMS coverage guidance
Mapped diagnoses and classifications
SNOMED_CT 28944009high
Cytomegalovirus infection
Source: SNOMED International ICD-10 map
SNOMED_CT 1085381000119108high
Cytomegalovirus viraemia
Source: SNOMED International ICD-10 map
SNOMED_CT 713722001high
Infection caused by Cytomegalovirus co-occurrent with human immunodeficiency virus infection
Source: SNOMED International ICD-10 map
Coding guidelines
Compatibility
Legacy and official ICD code match exactly.
Legacy codes
B25.9
Common synonyms
Cytomegaloviral disease, unspecifiedCytomegaloviral disease
Frequently asked questions
About this content
This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.