ICD10BillableValid for clinical use
ICD-10 Code C49.0: Malignant neoplasm of connective and soft tissue of head, face and neck
C49.0 is a billable ICD-10 diagnosis code used to classify Malignant neoplasm of connective and soft tissue of head, face and neck in medical records and claims. You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records. ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Neoplasms (C00-D49).
Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026
What is this code?
ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Neoplasms (C00-D49).
When is it used?
- May be used when a clinician documents malignant neoplasm of connective and soft tissue of head, face and neck in a patient's medical record.
- May appear in hospital records, claims, referrals, and clinical documentation.
- This code can be used as a clinically usable diagnosis entry in standardized coding workflows.
What it does not mean
- A code alone does not explain severity, treatment plan, or outcome.
- A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
Code hierarchy
chapter
2Neoplasms (C00-D49)
block
C00-C96Malignant neoplasms
block
C00-C75Malignant neoplasms, stated or presumed to be primary (of specified sites), and certain specified histologies, except neuroendocrine, and of lymphoid, hematopoietic and related tissue
block
C45-C49Malignant neoplasms of mesothelial and soft tissue
category
C49Malignant neoplasm of other connective and soft tissue
currentC49
Official coding notes
Inclusion terms
- Malignant neoplasm of connective tissue of ear
- Malignant neoplasm of connective tissue of eyelid
Excludes1 (do not code together)
- connective tissue of orbit (C69.6-)
Where you may see this code
You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.
Related specialists
OncologistGeneral Physician
Related codes
C49.1Malignant neoplasm of connective and soft tissue of upper limb, including shouldercategoryC49.2Malignant neoplasm of connective and soft tissue of lower limb, including hipcategoryC49.3Malignant neoplasm of connective and soft tissue of thoraxcodeC49.4Malignant neoplasm of connective and soft tissue of abdomencodeC49.5Malignant neoplasm of connective and soft tissue of pelviscodeC49.6Malignant neoplasm of connective and soft tissue of trunk, unspecifiedcodeC49.8Malignant neoplasm of overlapping sites of connective and soft tissuecodeC49.9Malignant neoplasm of connective and soft tissue, unspecifiedcodeC49.AGastrointestinal stromal tumorcategory
Sibling codes
C49.1Malignant neoplasm of connective and soft tissue of upper limb, including shoulderC49.2Malignant neoplasm of connective and soft tissue of lower limb, including hipC49.3Malignant neoplasm of connective and soft tissue of thoraxbillableC49.4Malignant neoplasm of connective and soft tissue of abdomenbillableC49.5Malignant neoplasm of connective and soft tissue of pelvisbillableC49.6Malignant neoplasm of connective and soft tissue of trunk, unspecifiedbillableC49.8Malignant neoplasm of overlapping sites of connective and soft tissuebillableC49.9Malignant neoplasm of connective and soft tissue, unspecifiedbillableC49.AGastrointestinal stromal tumor
Coverage-related procedures and services
CPT 81479high
UNLISTED MOLECULAR PATHOLOGY PROCEDURE
Source: CMS coverage guidance
CPT 81445high
SOLID ORGAN NEOPLASM, GENOMIC SEQUENCE ANALYSIS PANEL, 5-50 GENES, INTERROGATION FOR SEQUENCE VARIANTS AND COPY NUMBER VARIANTS OR REARRANGEMENTS, IF PERFORMED; DNA ANALYSIS OR COMBINED DNA AND RNA ANALYSIS
Source: CMS coverage guidance
CPT 0543Uhigh
ONCOLOGY (SOLID TUMOR), NEXT-GENERATION SEQUENCING OF DNA FROM FORMALIN-FIXED PARAFFIN-EMBEDDED (FFPE) TISSUE OF 517 GENES, INTERROGATION FOR SINGLE-NUCLEOTIDE VARIANTS, MULTI-NUCLEOTIDE VARIANTS, INSERTIONS AND DELETIONS FROM DNA, FUSIONS IN 24 GENES AND SPLICE VARIANTS IN 1 GENE FROM RNA, AND TUMOR MUTATION BURDEN
Source: CMS coverage guidance
CPT 17315high
MOHS MICROGRAPHIC TECHNIQUE, INCLUDING REMOVAL OF ALL GROSS TUMOR, SURGICAL EXCISION OF TISSUE SPECIMENS, MAPPING, COLOR CODING OF SPECIMENS, MICROSCOPIC EXAMINATION OF SPECIMENS BY THE SURGEON, AND HISTOPATHOLOGIC PREPARATION INCLUDING ROUTINE STAIN(S) (EG, HEMATOXYLIN AND EOSIN, TOLUIDINE BLUE), EACH ADDITIONAL BLOCK AFTER THE FIRST 5 TISSUE BLOCKS, ANY STAGE (LIST SEPARATELY IN ADDITION TO CODE FOR PRIMARY PROCEDURE)
Source: CMS coverage guidance
CPT 17312high
MOHS MICROGRAPHIC TECHNIQUE, INCLUDING REMOVAL OF ALL GROSS TUMOR, SURGICAL EXCISION OF TISSUE SPECIMENS, MAPPING, COLOR CODING OF SPECIMENS, MICROSCOPIC EXAMINATION OF SPECIMENS BY THE SURGEON, AND HISTOPATHOLOGIC PREPARATION INCLUDING ROUTINE STAIN(S) (EG, HEMATOXYLIN AND EOSIN, TOLUIDINE BLUE), HEAD, NECK, HANDS, FEET, GENITALIA, OR ANY LOCATION WITH SURGERY DIRECTLY INVOLVING MUSCLE, CARTILAGE, BONE, TENDON, MAJOR NERVES, OR VESSELS; EACH ADDITIONAL STAGE AFTER THE FIRST STAGE, UP TO 5 TISSUE BLOCKS (LIST SEPARATELY IN ADDITION TO CODE FOR PRIMARY PROCEDURE)
Source: CMS coverage guidance
CPT 17311high
MOHS MICROGRAPHIC TECHNIQUE, INCLUDING REMOVAL OF ALL GROSS TUMOR, SURGICAL EXCISION OF TISSUE SPECIMENS, MAPPING, COLOR CODING OF SPECIMENS, MICROSCOPIC EXAMINATION OF SPECIMENS BY THE SURGEON, AND HISTOPATHOLOGIC PREPARATION INCLUDING ROUTINE STAIN(S) (EG, HEMATOXYLIN AND EOSIN, TOLUIDINE BLUE), HEAD, NECK, HANDS, FEET, GENITALIA, OR ANY LOCATION WITH SURGERY DIRECTLY INVOLVING MUSCLE, CARTILAGE, BONE, TENDON, MAJOR NERVES, OR VESSELS; FIRST STAGE, UP TO 5 TISSUE BLOCKS
Source: CMS coverage guidance
Mapped diagnoses and classifications
SNOMED_CT 447757002high
Angiosarcoma of cheek
Source: SNOMED International ICD-10 map
SNOMED_CT 447706001high
Leiomyosarcoma of scalp
Source: SNOMED International ICD-10 map
SNOMED_CT 187987001high
Malignant neoplasm of cartilage of ear
Source: SNOMED International ICD-10 map
SNOMED_CT 363440005high
Malignant neoplasm of soft tissue of face
Source: SNOMED International ICD-10 map
SNOMED_CT 363439008high
Malignant neoplasm of soft tissue of head
Source: SNOMED International ICD-10 map
SNOMED_CT 302816009high
Malignant neoplasm of soft tissue of head and/or neck
Source: SNOMED International ICD-10 map
Coding guidelines
Compatibility
Legacy and official ICD code match exactly.
Legacy codes
C49.0
Common synonyms
Malignant neoplasm of connective and soft tissue of head, face and neck
Frequently asked questions
About this content
This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.