ICD10BillableValid for clinical use
ICD-10 Code C81.39: Lymphocyte depleted Hodgkin lymphoma, extranodal and solid organ sites
Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026
What is this code?
ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Neoplasms (C00-D49).
When is it used?
- May be used when a clinician documents lymphocyte depleted hodgkin lymphoma, extranodal and solid organ sites in a patient's medical record.
- May appear in hospital records, claims, referrals, and clinical documentation.
- This code can be used as a clinically usable diagnosis entry in standardized coding workflows.
What it does not mean
- A code alone does not explain severity, treatment plan, or outcome.
- A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
Code hierarchy
chapter
2Neoplasms (C00-D49)
block
C00-C96Malignant neoplasms
block
C81-C96Malignant neoplasms of lymphoid, hematopoietic and related tissue
category
C81Hodgkin lymphoma
category
C81.3Lymphocyte depleted Hodgkin lymphoma
currentC81.3
Where you may see this code
You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.
Related specialists
OncologistGeneral Physician
Related codes
C81.30Lymphocyte depleted Hodgkin lymphoma, unspecified sitecodeC81.31Lymphocyte depleted Hodgkin lymphoma, lymph nodes of head, face, and neckcodeC81.32Lymphocyte depleted Hodgkin lymphoma, intrathoracic lymph nodescodeC81.33Lymphocyte depleted Hodgkin lymphoma, intra-abdominal lymph nodescodeC81.34Lymphocyte depleted Hodgkin lymphoma, lymph nodes of axilla and upper limbcodeC81.35Lymphocyte depleted Hodgkin lymphoma, lymph nodes of inguinal region and lower limbcodeC81.36Lymphocyte depleted Hodgkin lymphoma, intrapelvic lymph nodescodeC81.37Lymphocyte depleted Hodgkin lymphoma, spleencodeC81.38Lymphocyte depleted Hodgkin lymphoma, lymph nodes of multiple sitescodeC81.3ALymphocyte depleted Hodgkin lymphoma, in remissioncode
Sibling codes
C81.30Lymphocyte depleted Hodgkin lymphoma, unspecified sitebillableC81.31Lymphocyte depleted Hodgkin lymphoma, lymph nodes of head, face, and neckbillableC81.32Lymphocyte depleted Hodgkin lymphoma, intrathoracic lymph nodesbillableC81.33Lymphocyte depleted Hodgkin lymphoma, intra-abdominal lymph nodesbillableC81.34Lymphocyte depleted Hodgkin lymphoma, lymph nodes of axilla and upper limbbillableC81.35Lymphocyte depleted Hodgkin lymphoma, lymph nodes of inguinal region and lower limbbillableC81.36Lymphocyte depleted Hodgkin lymphoma, intrapelvic lymph nodesbillableC81.37Lymphocyte depleted Hodgkin lymphoma, spleenbillableC81.38Lymphocyte depleted Hodgkin lymphoma, lymph nodes of multiple sitesbillableC81.3ALymphocyte depleted Hodgkin lymphoma, in remissionbillable
Coverage-related procedures and services
CPT 81479high
UNLISTED MOLECULAR PATHOLOGY PROCEDURE
Source: CMS coverage guidance
CPT 81450high
HEMATOLYMPHOID NEOPLASM OR DISORDER, GENOMIC SEQUENCE ANALYSIS PANEL, 5-50 GENES, INTERROGATION FOR SEQUENCE VARIANTS, AND COPY NUMBER VARIANTS OR REARRANGEMENTS, OR ISOFORM EXPRESSION OR MRNA EXPRESSION LEVELS, IF PERFORMED; DNA ANALYSIS OR COMBINED DNA AND RNA ANALYSIS
Source: CMS coverage guidance
CPT 38240high
HEMATOPOIETIC PROGENITOR CELL (HPC); ALLOGENEIC TRANSPLANTATION PER DONOR
Source: CMS coverage guidance
CPT 81263high
IGH@ (IMMUNOGLOBULIN HEAVY CHAIN LOCUS) (EG, LEUKEMIA AND LYMPHOMA, B-CELL), VARIABLE REGION SOMATIC MUTATION ANALYSIS
Source: CMS coverage guidance
CPT 81261high
IGH@ (IMMUNOGLOBULIN HEAVY CHAIN LOCUS) (EG, LEUKEMIAS AND LYMPHOMAS, B-CELL), GENE REARRANGEMENT ANALYSIS TO DETECT ABNORMAL CLONAL POPULATION(S); AMPLIFIED METHODOLOGY (EG, POLYMERASE CHAIN REACTION)
Source: CMS coverage guidance
CPT 81264high
IGK@ (IMMUNOGLOBULIN KAPPA LIGHT CHAIN LOCUS) (EG, LEUKEMIA AND LYMPHOMA, B-CELL), GENE REARRANGEMENT ANALYSIS, EVALUATION TO DETECT ABNORMAL CLONAL POPULATION(S)
Source: CMS coverage guidance
Coding guidelines
Common synonyms
Lymphocyte depleted Hodgkin lymphoma, extranodal and solid organ sites
Frequently asked questions
About this content
This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.