ICD10BillableValid for clinical use

ICD-10 Code C83.390: Primary central nervous system lymphoma

C83.390 is a billable ICD-10 diagnosis code used to classify Primary central nervous system lymphoma in medical records and claims. You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records. ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Neoplasms (C00-D49).

Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026

What is this code?

ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Neoplasms (C00-D49).

When is it used?

  • May be used when a clinician documents primary central nervous system lymphoma in a patient's medical record.
  • May appear in hospital records, claims, referrals, and clinical documentation.
  • This code can be used as a clinically usable diagnosis entry in standardized coding workflows.

What it does not mean

  • A code alone does not explain severity, treatment plan, or outcome.
  • A medical code should not be treated as a substitute for a doctor's diagnosis or advice.

Code hierarchy

chapter
2Neoplasms (C00-D49)
block
C00-C96Malignant neoplasms
block
C81-C96Malignant neoplasms of lymphoid, hematopoietic and related tissue
category
C83Non-follicular lymphoma
category
C83.3Diffuse large B-cell lymphoma
category
C83.39Diffuse large B-cell lymphoma, extranodal and solid organ sites
currentC83.39

Official coding notes

Inclusion terms
  • PCNSL of brain
  • PCNSL of meninges
  • PCNSL of spinal cord
  • PCNSL NOS
Excludes1 (do not code together)
  • Primary central nervous system lymphoma, Burkitt (C83.79)
  • Primary central nervous system lymphoma, lymphoblastic (C83.59)
  • Primary central nervous system lymphoma, other (C83.89)
  • Primary central nervous system lymphoma, peripheral T-cell (C84.49)

Where you may see this code

You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.

Related specialists

OncologistGeneral Physician

Coverage-related procedures and services

CPT 81479high
UNLISTED MOLECULAR PATHOLOGY PROCEDURE
Source: CMS coverage guidance
CPT 81450high
HEMATOLYMPHOID NEOPLASM OR DISORDER, GENOMIC SEQUENCE ANALYSIS PANEL, 5-50 GENES, INTERROGATION FOR SEQUENCE VARIANTS, AND COPY NUMBER VARIANTS OR REARRANGEMENTS, OR ISOFORM EXPRESSION OR MRNA EXPRESSION LEVELS, IF PERFORMED; DNA ANALYSIS OR COMBINED DNA AND RNA ANALYSIS
Source: CMS coverage guidance
CPT 81263high
IGH@ (IMMUNOGLOBULIN HEAVY CHAIN LOCUS) (EG, LEUKEMIA AND LYMPHOMA, B-CELL), VARIABLE REGION SOMATIC MUTATION ANALYSIS
Source: CMS coverage guidance
CPT 81261high
IGH@ (IMMUNOGLOBULIN HEAVY CHAIN LOCUS) (EG, LEUKEMIAS AND LYMPHOMAS, B-CELL), GENE REARRANGEMENT ANALYSIS TO DETECT ABNORMAL CLONAL POPULATION(S); AMPLIFIED METHODOLOGY (EG, POLYMERASE CHAIN REACTION)
Source: CMS coverage guidance
CPT 81264high
IGK@ (IMMUNOGLOBULIN KAPPA LIGHT CHAIN LOCUS) (EG, LEUKEMIA AND LYMPHOMA, B-CELL), GENE REARRANGEMENT ANALYSIS, EVALUATION TO DETECT ABNORMAL CLONAL POPULATION(S)
Source: CMS coverage guidance
CPT 81540high
ONCOLOGY (TUMOR OF UNKNOWN ORIGIN), MRNA, GENE EXPRESSION PROFILING BY REAL-TIME RT-PCR OF 92 GENES (87 CONTENT AND 5 HOUSEKEEPING) TO CLASSIFY TUMOR INTO MAIN CANCER TYPE AND SUBTYPE, UTILIZING FORMALIN-FIXED PARAFFIN-EMBEDDED TISSUE, ALGORITHM REPORTED AS A PROBABILITY OF A PREDICTED MAIN CANCER TYPE AND SUBTYPE
Source: CMS coverage guidance

Coding guidelines

Common synonyms

Primary central nervous system lymphoma

Frequently asked questions

Code details

CodeC83.390
SystemICD10
Display namePrimary central nervous system lymphoma
ChapterNeoplasms (C00-D49)
BlockMalignant neoplasms of lymphoid, hematopoietic and related tissue

Flags

BillableYes
Valid clinical useYes

Source

SourceICD-10
Version2026-annual
Releaseannual
Year2026

Index terms

Matched terms
Lymphoma(of) (malignant)Lymphoma(of) (malignant)Lymphoma(of) (malignant)

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.

ICD-10 Code C83.390 for Primary central nervous system lymphoma | HealthAssure