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ICD-10 Code C96.0: Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis

C96.0 is a billable ICD-10 diagnosis code used to classify Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis in medical records and claims. You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records. ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Neoplasms (C00-D49).

What is this code?

ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Neoplasms (C00-D49).

When is it used?

  • May be used when a clinician documents multifocal and multisystemic (disseminated) langerhans-cell histiocytosis in a patient's medical record.
  • May appear in hospital records, claims, referrals, and clinical documentation.
  • This code can be used as a clinically usable diagnosis entry in standardized coding workflows.

What it does not mean

  • A code alone does not explain severity, treatment plan, or outcome.
  • A medical code should not be treated as a substitute for a doctor's diagnosis or advice.

Code hierarchy

chapter
2Neoplasms (C00-D49)
block
C00-C96Malignant neoplasms
block
C81-C96Malignant neoplasms of lymphoid, hematopoietic and related tissue
category
C96Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue
currentC96

Official coding notes

Inclusion terms
  • Histiocytosis X, multisystemic
  • Letterer-Siwe disease
Excludes1 (do not code together)
  • adult pulmonary Langerhans cell histiocytosis (J84.82)
  • multifocal and unisystemic Langerhans-cell histiocytosis (C96.5)
  • unifocal Langerhans-cell histiocytosis (C96.6)

Where you may see this code

You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.

Related specialists

OncologistGeneral Physician

Coverage-related procedures and services

CPT 81479high
UNLISTED MOLECULAR PATHOLOGY PROCEDURE
Source: CMS coverage guidance
CPT 81450high
HEMATOLYMPHOID NEOPLASM OR DISORDER, GENOMIC SEQUENCE ANALYSIS PANEL, 5-50 GENES, INTERROGATION FOR SEQUENCE VARIANTS, AND COPY NUMBER VARIANTS OR REARRANGEMENTS, OR ISOFORM EXPRESSION OR MRNA EXPRESSION LEVELS, IF PERFORMED; DNA ANALYSIS OR COMBINED DNA AND RNA ANALYSIS
Source: CMS coverage guidance
CPT 88182high
FLOW CYTOMETRY, CELL CYCLE OR DNA ANALYSIS
Source: CMS coverage guidance
CPT 88185high
FLOW CYTOMETRY, CELL SURFACE, CYTOPLASMIC, OR NUCLEAR MARKER, TECHNICAL COMPONENT ONLY; EACH ADDITIONAL MARKER (LIST SEPARATELY IN ADDITION TO CODE FOR FIRST MARKER)
Source: CMS coverage guidance
CPT 88184high
FLOW CYTOMETRY, CELL SURFACE, CYTOPLASMIC, OR NUCLEAR MARKER, TECHNICAL COMPONENT ONLY; FIRST MARKER
Source: CMS coverage guidance
CPT 88189high
FLOW CYTOMETRY, INTERPRETATION; 16 OR MORE MARKERS
Source: CMS coverage guidance

Mapped diagnoses and classifications

Coding guidelines

Compatibility

Legacy and official ICD code match exactly.
Legacy codes
C96.0

Common synonyms

Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosisMultifocal and multisystemicMultifocal and multisystemic disseminated Langerhans-cell histiocytosis

Frequently asked questions

Code details

CodeC96.0
SystemICD10
Display nameMultifocal and multisystemic (disseminated) Langerhans-cell histiocytosis
ChapterNeoplasms (C00-D49)
BlockMalignant neoplasms of lymphoid, hematopoietic and related tissue

Flags

BillableYes
Valid clinical useYes

Source

SourceICD-10
Version2026-annual
Releaseannual
Year2026

Index terms

Matched terms
HistiocytosisHistiocytosisHistiocytosisHistiocytosisLetterer-Siwe's diseaseReticuloendotheliosisReticuloendotheliosisReticulosis(skin)

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.