ICD10BillableValid for clinical use
ICD-10 Code D45: Polycythemia vera
Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026
What is this code?
ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Neoplasms (C00-D49).
When is it used?
- May be used when a clinician documents polycythemia vera in a patient's medical record.
- May appear in hospital records, claims, referrals, and clinical documentation.
- This code can be used as a clinically usable diagnosis entry in standardized coding workflows.
What it does not mean
- A code alone does not explain severity, treatment plan, or outcome.
- A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
Code hierarchy
chapter
2Neoplasms (C00-D49)
block
D37-D48Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
currentD37-D48
Official coding notes
Excludes1 (do not code together)
- familial polycythemia (D75.0)
- secondary polycythemia (D75.1)
Where you may see this code
You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.
Related specialists
OncologistGeneral Physician
Related codes
D37Neoplasm of uncertain behavior of oral cavity and digestive organscategoryD38Neoplasm of uncertain behavior of middle ear and respiratory and intrathoracic organscategoryD39Neoplasm of uncertain behavior of female genital organscategoryD40Neoplasm of uncertain behavior of male genital organscategoryD41Neoplasm of uncertain behavior of urinary organscategoryD42Neoplasm of uncertain behavior of meningescategoryD43Neoplasm of uncertain behavior of brain and central nervous systemcategoryD44Neoplasm of uncertain behavior of endocrine glandscategoryD46Myelodysplastic syndromescategoryD47Other neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissuecategoryD48Neoplasm of uncertain behavior of other and unspecified sitescategory
Sibling codes
Coverage-related procedures and services
CPT 81479high
UNLISTED MOLECULAR PATHOLOGY PROCEDURE
Source: CMS coverage guidance
CPT 81450high
HEMATOLYMPHOID NEOPLASM OR DISORDER, GENOMIC SEQUENCE ANALYSIS PANEL, 5-50 GENES, INTERROGATION FOR SEQUENCE VARIANTS, AND COPY NUMBER VARIANTS OR REARRANGEMENTS, OR ISOFORM EXPRESSION OR MRNA EXPRESSION LEVELS, IF PERFORMED; DNA ANALYSIS OR COMBINED DNA AND RNA ANALYSIS
Source: CMS coverage guidance
CPT 0040Uhigh
BCR/ABL1 (T(9;22)) (EG, CHRONIC MYELOGENOUS LEUKEMIA) TRANSLOCATION ANALYSIS, MAJOR BREAKPOINT, QUANTITATIVE
Source: CMS coverage guidance
CPT 81206high
BCR/ABL1 (T(9;22)) (EG, CHRONIC MYELOGENOUS LEUKEMIA) TRANSLOCATION ANALYSIS; MAJOR BREAKPOINT, QUALITATIVE OR QUANTITATIVE
Source: CMS coverage guidance
CPT 81207high
BCR/ABL1 (T(9;22)) (EG, CHRONIC MYELOGENOUS LEUKEMIA) TRANSLOCATION ANALYSIS; MINOR BREAKPOINT, QUALITATIVE OR QUANTITATIVE
Source: CMS coverage guidance
CPT 81208high
BCR/ABL1 (T(9;22)) (EG, CHRONIC MYELOGENOUS LEUKEMIA) TRANSLOCATION ANALYSIS; OTHER BREAKPOINT, QUALITATIVE OR QUANTITATIVE
Source: CMS coverage guidance
Mapped diagnoses and classifications
Coding guidelines
Compatibility
Legacy and official ICD code match exactly.
Legacy codes
D45
Common synonyms
Polycythemia vera
Frequently asked questions
About this content
This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.