ICD10BillableValid for clinical use

ICD-10 Code D55.21: Anemia due to pyruvate kinase deficiency

D55.21 is a billable ICD-10 diagnosis code used to classify Anemia due to pyruvate kinase deficiency in medical records and claims. You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records. ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89).

Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026

What is this code?

ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89).

When is it used?

  • May be used when a clinician documents anemia due to pyruvate kinase deficiency in a patient's medical record.
  • May appear in hospital records, claims, referrals, and clinical documentation.
  • This code can be used as a clinically usable diagnosis entry in standardized coding workflows.

What it does not mean

  • A code alone does not explain severity, treatment plan, or outcome.
  • A medical code should not be treated as a substitute for a doctor's diagnosis or advice.

Code hierarchy

chapter
3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
block
D55-D59Hemolytic anemias
category
D55Anemia due to enzyme disorders
category
D55.2Anemia due to disorders of glycolytic enzymes
currentD55.2

Official coding notes

Inclusion terms
  • PK deficiency anemia
  • Pyruvate kinase deficiency anemia

Where you may see this code

You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.

Related specialists

HematologistGeneral Physician

Coding guidelines

Common synonyms

Anemia due to pyruvate kinase deficiency

Frequently asked questions

Code details

CodeD55.21
SystemICD10
Display nameAnemia due to pyruvate kinase deficiency
ChapterDiseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
BlockHemolytic anemias

Flags

BillableYes
Valid clinical useYes

Source

SourceICD-10
Version2026-annual
Releaseannual
Year2026

Index terms

Matched terms
Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.