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ICD-10 Code D56.3: Thalassemia minor

D56.3 is a billable ICD-10 diagnosis code used to classify Thalassemia minor in medical records and claims. You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records. ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89).

Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026

What is this code?

ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89).

When is it used?

  • May be used when a clinician documents thalassemia minor in a patient's medical record.
  • May appear in hospital records, claims, referrals, and clinical documentation.
  • This code can be used as a clinically usable diagnosis entry in standardized coding workflows.

What it does not mean

  • A code alone does not explain severity, treatment plan, or outcome.
  • A medical code should not be treated as a substitute for a doctor's diagnosis or advice.

Code hierarchy

chapter
3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
block
D55-D59Hemolytic anemias
category
D56Thalassemia
currentD56

Official coding notes

Inclusion terms
  • Alpha thalassemia minor
  • Alpha thalassemia silent carrier
  • Alpha thalassemia trait
  • Beta thalassemia minor
  • Beta thalassemia trait
  • Delta-beta thalassemia minor
  • Delta-beta thalassemia trait
  • Thalassemia trait NOS
Excludes1 (do not code together)
  • alpha thalassemia (D56.0)
  • beta thalassemia (D56.1)
  • delta-beta thalassemia (D56.2)
  • hemoglobin E-beta thalassemia (D56.5)
  • sickle-cell trait (D57.3)

Where you may see this code

You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.

Related specialists

HematologistGeneral Physician

Coverage-related procedures and services

CPT 81403high
MOLECULAR PATHOLOGY PROCEDURE, LEVEL 4 (EG, ANALYSIS OF SINGLE EXON BY DNA SEQUENCE ANALYSIS, ANALYSIS OF >10 AMPLICONS USING MULTIPLEX PCR IN 2 OR MORE INDEPENDENT REACTIONS, MUTATION SCANNING OR DUPLICATION/DELETION VARIANTS OF 2-5 EXONS)
Source: CMS coverage guidance
CPT 0084Uhigh
RED BLOOD CELL ANTIGEN TYPING, DNA, GENOTYPING OF 10 BLOOD GROUPS WITH PHENOTYPE PREDICTION OF 37 RED BLOOD CELL ANTIGENS
Source: CMS coverage guidance
CPT 0001Uhigh
RED BLOOD CELL ANTIGEN TYPING, DNA, HUMAN ERYTHROCYTE ANTIGEN GENE ANALYSIS OF 35 ANTIGENS FROM 11 BLOOD GROUPS, UTILIZING WHOLE BLOOD, COMMON RBC ALLELES REPORTED
Source: CMS coverage guidance
CPT 88182high
FLOW CYTOMETRY, CELL CYCLE OR DNA ANALYSIS
Source: CMS coverage guidance
CPT 88185high
FLOW CYTOMETRY, CELL SURFACE, CYTOPLASMIC, OR NUCLEAR MARKER, TECHNICAL COMPONENT ONLY; EACH ADDITIONAL MARKER (LIST SEPARATELY IN ADDITION TO CODE FOR FIRST MARKER)
Source: CMS coverage guidance
CPT 88184high
FLOW CYTOMETRY, CELL SURFACE, CYTOPLASMIC, OR NUCLEAR MARKER, TECHNICAL COMPONENT ONLY; FIRST MARKER
Source: CMS coverage guidance

Coding guidelines

Compatibility

Legacy and official ICD code match exactly.
Legacy codes
D56.3

Common synonyms

Thalassemia minor

Frequently asked questions

Code details

CodeD56.3
SystemICD10
Display nameThalassemia minor
ChapterDiseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
BlockHemolytic anemias

Flags

BillableYes
Valid clinical useYes

Source

SourceICD-10
Version2026-annual
Releaseannual
Year2026

Index terms

Matched terms
Thalassemia(anemia) (disease)Thalassemia(anemia) (disease)Thalassemia(anemia) (disease)Thalassemia(anemia) (disease)Thalassemia(anemia) (disease)Thalassemia(anemia) (disease)Thalassemia(anemia) (disease)Thalassemia(anemia) (disease)Thalassemia(anemia) (disease)Trait(s)Trait(s)

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.

ICD-10 Code D56.3 for Thalassemia minor | HealthAssure