What does ICD-10 code D61.81 mean?

ICD-10 code D61.81 is the standardized code used for pancytopenia in medical records and coding systems.

When is ICD-10 code D61.81 used?

Doctors, hospitals, and insurers may use ICD-10 code D61.81 when recording pancytopenia in a standardized format. This entry may also act as a broader category that points toward more specific child codes.

Does ICD-10 code D61.81 confirm a diagnosis?

No. A code helps standardize documentation and claims, but it should not be read as a substitute for a clinician's full assessment.

ICD10

ICD-10 Code D61.81: Pancytopenia

Name: ICD-10 Code D61.81: Pancytopenia
Creator: HealthAssure Clinical Team
Published: 2026-05-21T06:04:25.256Z

D61.81 is an ICD-10 diagnosis entry used to group records related to Pancytopenia. You may see this entry in coding references, medical records, or claims workflows when a broader diagnosis category is being reviewed before a more specific code is chosen. ICD-10 entries help standardize how diagnoses are organized for coding, reporting, analytics, and documentation. This code sits within the broader ICD-10 area for Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89).

Reviewed by HealthAssure Clinical TeamUpdated 21 May 2026

What is this code?

ICD-10 entries help standardize how diagnoses are organized for coding, reporting, analytics, and documentation. This code sits within the broader ICD-10 area for Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89).

When is it used?

May be used when a clinician documents pancytopenia in a patient's medical record.
May appear in hospital records, claims, referrals, and clinical documentation.
This code may act more like a grouping or parent code, so a more specific child code may be used in final documentation when available.

What it does not mean

A code alone does not explain severity, treatment plan, or outcome.
A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
This entry may represent a broader category rather than the most specific billable code.

Code hierarchy

chapter

3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

block

D60-D64Aplastic and other anemias and other bone marrow failure syndromes

Official coding notes

Excludes1 (do not code together)

pancytopenia (due to) (with) aplastic anemia (D61.9)
pancytopenia (due to) (with) bone marrow infiltration (D61.82)
pancytopenia (due to) (with) congenital (pure) red cell aplasia (D61.01)
pancytopenia (due to) (with) hairy cell leukemia (C91.4-)
pancytopenia (due to) (with) human immunodeficiency virus disease (B20.-)
pancytopenia (due to) (with) leukoerythroblastic anemia (D61.82)
pancytopenia (due to) (with) myeloproliferative disease (D47.1)

Excludes2 (may code together if documented)

pancytopenia (due to) (with) myelodysplastic syndromes (D46.-)

Where you may see this code

You may see this entry in coding references, medical records, or claims workflows when a broader diagnosis category is being reviewed before a more specific code is chosen.

Related specialists

HematologistGeneral Physician

Sibling codes

D61.82Myelophthisisbillable D61.89Other specified aplastic anemias and other bone marrow failure syndromesbillable

Coding guidelines

Common synonyms

Pancytopenia

Frequently asked questions

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.