HealthAssure
HealthAssureGood Life
ICD10BillableValid for clinical use

ICD-10 Code D82.4: Hyperimmunoglobulin E [IgE] syndrome

D82.4 is a billable ICD-10 diagnosis code used to classify Hyperimmunoglobulin E [IgE] syndrome in medical records and claims. You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records. ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89).

Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026

What is this code?

ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89).

When is it used?

  • May be used when a clinician documents hyperimmunoglobulin e [ige] syndrome in a patient's medical record.
  • May appear in hospital records, claims, referrals, and clinical documentation.
  • This code can be used as a clinically usable diagnosis entry in standardized coding workflows.

What it does not mean

  • A code alone does not explain severity, treatment plan, or outcome.
  • A medical code should not be treated as a substitute for a doctor's diagnosis or advice.

Code hierarchy

chapter
3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
block
D80-D89Certain disorders involving the immune mechanism
category
D82Immunodeficiency associated with other major defects
currentD82

Where you may see this code

You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.

Related specialists

HematologistGeneral Physician

Coverage-related procedures and services

HCPCS J1569high
INJECTION, IMMUNE GLOBULIN, (GAMMAGARD LIQUID), NON-LYOPHILIZED, (E.G., LIQUID), 500 MG
Source: CMS coverage guidance
HCPCS J1561high
INJECTION, IMMUNE GLOBULIN, (GAMUNEX-C/GAMMAKED), NON-LYOPHILIZED (E.G., LIQUID), 500 MG
Source: CMS coverage guidance
CPT 87507high
INFECTIOUS AGENT DETECTION BY NUCLEIC ACID (DNA OR RNA); GASTROINTESTINAL PATHOGEN (EG, CLOSTRIDIUM DIFFICILE, E. COLI, SALMONELLA, SHIGELLA, NOROVIRUS, GIARDIA), INCLUDES MULTIPLEX REVERSE TRANSCRIPTION, WHEN PERFORMED, AND MULTIPLEX AMPLIFIED PROBE TECHNIQUE, MULTIPLE TYPES OR SUBTYPES, 12-25 TARGETS
Source: CMS coverage guidance
CPT 87506high
INFECTIOUS AGENT DETECTION BY NUCLEIC ACID (DNA OR RNA); GASTROINTESTINAL PATHOGEN (EG, CLOSTRIDIUM DIFFICILE, E. COLI, SALMONELLA, SHIGELLA, NOROVIRUS, GIARDIA), INCLUDES MULTIPLEX REVERSE TRANSCRIPTION, WHEN PERFORMED, AND MULTIPLEX AMPLIFIED PROBE TECHNIQUE, MULTIPLE TYPES OR SUBTYPES, 6-11 TARGETS
Source: CMS coverage guidance
HCPCS J1556high
INJECTION, IMMUNE GLOBULIN (BIVIGAM), 500 MG
Source: CMS coverage guidance
HCPCS J1459high
INJECTION, IMMUNE GLOBULIN (PRIVIGEN), INTRAVENOUS, NON-LYOPHILIZED (E.G., LIQUID), 500 MG
Source: CMS coverage guidance

Mapped diagnoses and classifications

SNOMED_CT 1351324009high
Autosomal dominant combined immunodeficiency due to ERBIN deficiency
Source: SNOMED International ICD-10 map
SNOMED_CT 1351325005high
Autosomal dominant combined immunodeficiency due to partial IL6ST deficiency
Source: SNOMED International ICD-10 map
SNOMED_CT 1351326006high
Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency
Source: SNOMED International ICD-10 map
SNOMED_CT 1351327002high
Autosomal recessive combined immunodeficiency due to IL6R deficiency
Source: SNOMED International ICD-10 map
SNOMED_CT 1351328007high
Autosomal recessive combined immunodeficiency due to complete IL6ST deficiency
Source: SNOMED International ICD-10 map
SNOMED_CT 1351329004high
Autosomal recessive combined immunodeficiency due to partial IL6ST deficiency
Source: SNOMED International ICD-10 map

Coding guidelines

Compatibility

Legacy and official ICD code match exactly.
Legacy codes
D82.4

Common synonyms

Hyperimmunoglobulin E [IgE] syndrome

Frequently asked questions

Code details

CodeD82.4
SystemICD10
Display nameHyperimmunoglobulin E [IgE] syndrome
ChapterDiseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
BlockCertain disorders involving the immune mechanism

Flags

BillableYes
Valid clinical useYes

Source

SourceICD-10
Version2026-annual
Releaseannual
Year2026

Index terms

Matched terms
Syndrome

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.

ICD-10 Code D82.4 for Hyperimmunoglobulin E [IgE] syndrome | HealthAssure