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ICD10BillableValid for clinical use

ICD-10 Code E08.43: Diabetes mellitus due to underlying condition with diabetic autonomic (poly)neuropathy

E08.43 is a billable ICD-10 diagnosis code used to classify Diabetes mellitus due to underlying condition with diabetic autonomic (poly)neuropathy in medical records and claims. You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records. ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Endocrine, nutritional and metabolic diseases (E00-E89).

What is this code?

ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Endocrine, nutritional and metabolic diseases (E00-E89).

šŸ“‹Clinical overview

This ICD-10 code is commonly used when documentation describes diabetes or diabetes-related clinical context. The exact code selection depends on the diabetes type, whether complications are documented, and how specific the charting is.

When is it used?

  • May be used when a clinician documents diabetes mellitus due to underlying condition with diabetic autonomic (poly)neuropathy in a patient's medical record.
  • May appear in hospital records, claims, referrals, and clinical documentation.
  • This code can be used as a clinically usable diagnosis entry in standardized coding workflows.

What it does not mean

  • A code alone does not explain severity, treatment plan, or outcome.
  • A medical code should not be treated as a substitute for a doctor's diagnosis or advice.

šŸ©ŗClinical context

When commonly used
  • Outpatient and inpatient documentation where diabetes is an active diagnosis or part of chronic disease management.
  • Risk adjustment, utilization review, and continuity-of-care summaries where diabetes status needs to be carried forward.
Common management context
  • Diabetes care often involves primary care, endocrinology, eye screening, kidney-risk monitoring, and foot-care follow-up.
  • Medication reconciliation and longitudinal follow-up matter because treatment intensity and complication status can change over time.
  • Specialist context already linked on this page includes Endocrinologist, General Physician.

šŸ”Key distinctions

Important notes
  • ICD-10 diabetes coding usually becomes more specific when the record documents complications such as kidney disease, neuropathy, retinopathy, ulcers, or hypoglycemia.
  • If the record identifies the diabetes type or a complication clearly, a more detailed family code may be more appropriate than a broad default code.
Related codes to consider
E08.40Diabetes mellitus due to underlying condition with diabetic neuropathy, unspecified
Related diabetes-family ICD-10 code; documentation often becomes more specific when type or complication detail is available.
E08.41Diabetes mellitus due to underlying condition with diabetic mononeuropathy
Related diabetes-family ICD-10 code; documentation often becomes more specific when type or complication detail is available.
E08.42Diabetes mellitus due to underlying condition with diabetic polyneuropathy
Related diabetes-family ICD-10 code; documentation often becomes more specific when type or complication detail is available.
E08.44Diabetes mellitus due to underlying condition with diabetic amyotrophy
Related diabetes-family ICD-10 code; documentation often becomes more specific when type or complication detail is available.

Code hierarchy

chapter
4Endocrine, nutritional and metabolic diseases (E00-E89)
block
E08-E13Diabetes mellitus
category
E08Diabetes mellitus due to underlying condition
category
E08.4Diabetes mellitus due to underlying condition with neurological complications
currentE08.4

Official coding notes

Inclusion terms
  • Diabetes mellitus due to underlying condition with diabetic gastroparesis

Where you may see this code

You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.

Related specialists

EndocrinologistGeneral Physician

Coverage-related procedures and services

CPT 0446Thigh
CREATION OF SUBCUTANEOUS POCKET WITH INSERTION OF IMPLANTABLE INTERSTITIAL GLUCOSE SENSOR, INCLUDING SYSTEM ACTIVATION AND PATIENT TRAINING
Source: CMS coverage guidance
CPT 0448Thigh
REMOVAL OF IMPLANTABLE INTERSTITIAL GLUCOSE SENSOR WITH CREATION OF SUBCUTANEOUS POCKET AT DIFFERENT ANATOMIC SITE AND INSERTION OF NEW IMPLANTABLE SENSOR, INCLUDING SYSTEM ACTIVATION
Source: CMS coverage guidance
CPT 51785high
NEEDLE ELECTROMYOGRAPHY STUDIES (EMG) OF ANAL OR URETHRAL SPHINCTER, ANY TECHNIQUE
Source: CMS coverage guidance
HCPCS G0255high
CURRENT PERCEPTION THRESHOLD/SENSORY NERVE CONDUCTION TEST, (SNCT) PER LIMB, ANY NERVE
Source: CMS coverage guidance
CPT 87507high
INFECTIOUS AGENT DETECTION BY NUCLEIC ACID (DNA OR RNA); GASTROINTESTINAL PATHOGEN (EG, CLOSTRIDIUM DIFFICILE, E. COLI, SALMONELLA, SHIGELLA, NOROVIRUS, GIARDIA), INCLUDES MULTIPLEX REVERSE TRANSCRIPTION, WHEN PERFORMED, AND MULTIPLEX AMPLIFIED PROBE TECHNIQUE, MULTIPLE TYPES OR SUBTYPES, 12-25 TARGETS
Source: CMS coverage guidance
CPT 87506high
INFECTIOUS AGENT DETECTION BY NUCLEIC ACID (DNA OR RNA); GASTROINTESTINAL PATHOGEN (EG, CLOSTRIDIUM DIFFICILE, E. COLI, SALMONELLA, SHIGELLA, NOROVIRUS, GIARDIA), INCLUDES MULTIPLEX REVERSE TRANSCRIPTION, WHEN PERFORMED, AND MULTIPLEX AMPLIFIED PROBE TECHNIQUE, MULTIPLE TYPES OR SUBTYPES, 6-11 TARGETS
Source: CMS coverage guidance

Coding guidelines

Common synonyms

Diabetes mellitus due to underlying condition with diabetic autonomic (poly)neuropathyDiabetes mellitus due to underlying condition with diabetic autonomicDiabetes mellitus due to underlying condition with diabetic autonomic poly neuropathy

Frequently asked questions

Code details

CodeE08.43
SystemICD10
Display nameDiabetes mellitus due to underlying condition with diabetic autonomic (poly)neuropathy
ChapterEndocrine, nutritional and metabolic diseases (E00-E89)
BlockDiabetes mellitus

Flags

BillableYes
Valid clinical useYes

Source

SourceICD-10
Version2026-annual
Releaseannual
Year2026

Index terms

Matched terms
Diabetes, diabetic(mellitus) (sugar)Diabetes, diabetic(mellitus) (sugar)Diabetes, diabetic(mellitus) (sugar)

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.