ICD10BillableValid for clinical use

ICD-10 Code E21.0: Primary hyperparathyroidism

E21.0 is a billable ICD-10 diagnosis code used to classify Primary hyperparathyroidism in medical records and claims. You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records. ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Endocrine, nutritional and metabolic diseases (E00-E89).

Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026

What is this code?

ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Endocrine, nutritional and metabolic diseases (E00-E89).

When is it used?

  • May be used when a clinician documents primary hyperparathyroidism in a patient's medical record.
  • May appear in hospital records, claims, referrals, and clinical documentation.
  • This code can be used as a clinically usable diagnosis entry in standardized coding workflows.

What it does not mean

  • A code alone does not explain severity, treatment plan, or outcome.
  • A medical code should not be treated as a substitute for a doctor's diagnosis or advice.

Code hierarchy

chapter
4Endocrine, nutritional and metabolic diseases (E00-E89)
block
E20-E35Disorders of other endocrine glands
category
E21Hyperparathyroidism and other disorders of parathyroid gland
currentE21

Official coding notes

Inclusion terms
  • Hyperplasia of parathyroid
  • Osteitis fibrosa cystica generalisata [von Recklinghausen's disease of bone]

Where you may see this code

You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.

Related specialists

EndocrinologistGeneral Physician

Coverage-related procedures and services

CPT 82306high
VITAMIN D; 25 HYDROXY, INCLUDES FRACTION(S), IF PERFORMED
Source: CMS coverage guidance
CPT 82652high
VITAMIN D; 1, 25 DIHYDROXY, INCLUDES FRACTION(S), IF PERFORMED
Source: CMS coverage guidance
CPT 78351high
BONE DENSITY (BONE MINERAL CONTENT) STUDY, 1 OR MORE SITES; DUAL PHOTON ABSORPTIOMETRY, 1 OR MORE SITES
Source: CMS coverage guidance
CPT 78350high
BONE DENSITY (BONE MINERAL CONTENT) STUDY, 1 OR MORE SITES; SINGLE PHOTON ABSORPTIOMETRY
Source: CMS coverage guidance
CPT 0556Thigh
BONE STRENGTH AND FRACTURE RISK USING FINITE ELEMENT ANALYSIS OF FUNCTIONAL DATA AND BONE-MINERAL DENSITY UTILIZING DATA FROM A COMPUTED TOMOGRAPHY SCAN; ASSESSMENT OF BONE STRENGTH AND FRACTURE RISK AND BONE-MINERAL DENSITY
Source: CMS coverage guidance
CPT 0557Thigh
BONE STRENGTH AND FRACTURE RISK USING FINITE ELEMENT ANALYSIS OF FUNCTIONAL DATA AND BONE-MINERAL DENSITY UTILIZING DATA FROM A COMPUTED TOMOGRAPHY SCAN; INTERPRETATION AND REPORT
Source: CMS coverage guidance

Coding guidelines

Compatibility

Legacy and official ICD code match exactly.
Legacy codes
E21.0

Common synonyms

Primary hyperparathyroidism

Frequently asked questions

Code details

CodeE21.0
SystemICD10
Display namePrimary hyperparathyroidism
ChapterEndocrine, nutritional and metabolic diseases (E00-E89)
BlockDisorders of other endocrine glands

Flags

BillableYes
Valid clinical useYes

Source

SourceICD-10
Version2026-annual
Releaseannual
Year2026

Index terms

Matched terms
CurvatureDisease, diseasedEnlargement, enlargedHyperparathyroidismHyperplasia, hyperplasticHypertrophy, hypertrophicOsteitisOsteitisOsteitisRecklinghausen diseaseVon Recklinghausen
See also
subcategory M49.8

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.

ICD-10 Code E21.0 for Primary hyperparathyroidism | HealthAssure