What does ICD-10 code E22 mean?

ICD-10 code E22 is the standardized code used for hyperfunction of pituitary gland in medical records and coding systems.

When is ICD-10 code E22 used?

Doctors, hospitals, and insurers may use ICD-10 code E22 when recording hyperfunction of pituitary gland in a standardized format. This entry may also act as a broader category that points toward more specific child codes.

Does ICD-10 code E22 confirm a diagnosis?

No. A code helps standardize documentation and claims, but it should not be read as a substitute for a clinician's full assessment.

ICD10

ICD-10 Code E22: Hyperfunction of pituitary gland

Name: ICD-10 Code E22: Hyperfunction of pituitary gland
Creator: HealthAssure Clinical Team
Published: 2026-05-21T06:05:04.538Z

E22 is an ICD-10 diagnosis entry used to group records related to Hyperfunction of pituitary gland. You may see this entry in coding references, medical records, or claims workflows when a broader diagnosis category is being reviewed before a more specific code is chosen. ICD-10 entries help standardize how diagnoses are organized for coding, reporting, analytics, and documentation. This code sits within the broader ICD-10 area for Endocrine, nutritional and metabolic diseases (E00-E89).

Reviewed by HealthAssure Clinical TeamUpdated 21 May 2026

What is this code?

ICD-10 entries help standardize how diagnoses are organized for coding, reporting, analytics, and documentation. This code sits within the broader ICD-10 area for Endocrine, nutritional and metabolic diseases (E00-E89).

When is it used?

May be used when a clinician documents hyperfunction of pituitary gland in a patient's medical record.
May appear in hospital records, claims, referrals, and clinical documentation.
This code may act more like a grouping or parent code, so a more specific child code may be used in final documentation when available.

What it does not mean

A code alone does not explain severity, treatment plan, or outcome.
A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
This entry may represent a broader category rather than the most specific billable code.

Code hierarchy

chapter

4Endocrine, nutritional and metabolic diseases (E00-E89)

block

E20-E35Disorders of other endocrine glands

currentE20-E35

Official coding notes

Excludes1 (do not code together)

Cushing's syndrome (E24.-)
Nelson's syndrome (E24.1)
overproduction of ACTH not associated with Cushing's disease (E27.0)
overproduction of pituitary ACTH (E24.0)
overproduction of thyroid-stimulating hormone (E05.8-)

Where you may see this code

You may see this entry in coding references, medical records, or claims workflows when a broader diagnosis category is being reviewed before a more specific code is chosen.

Related specialists

EndocrinologistGeneral Physician

Sibling codes

E20Hypoparathyroidism E21Hyperparathyroidism and other disorders of parathyroid gland E23Hypofunction and other disorders of the pituitary gland E24Cushing's syndrome E25Adrenogenital disorders E26Hyperaldosteronism E27Other disorders of adrenal gland E28Ovarian dysfunction E29Testicular dysfunction E30Disorders of puberty, not elsewhere classified E31Polyglandular dysfunction E32Diseases of thymus E34Other endocrine disorders E35Disorders of endocrine glands in diseases classified elsewherebillable

Coding guidelines

Compatibility

Legacy code aligns to an official FY 2026 category. Frontend should resolve to the official category page and surface the billable child codes.

Legacy codes

E22

Replacement codes

E22.0 — Acromegaly and pituitary gigantismE22.1 — HyperprolactinemiaE22.2 — Syndrome of inappropriate secretion of antidiuretic hormoneE22.8 — Other hyperfunction of pituitary glandE22.9 — Hyperfunction of pituitary gland, unspecified

Common synonyms

Hyperfunction of pituitary gland

Frequently asked questions

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.