ICD10BillableValid for clinical use
ICD-10 Code E31.8: Other polyglandular dysfunction
Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026
What is this code?
ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Endocrine, nutritional and metabolic diseases (E00-E89).
When is it used?
- May be used when a clinician documents other polyglandular dysfunction in a patient's medical record.
- May appear in hospital records, claims, referrals, and clinical documentation.
- This code can be used as a clinically usable diagnosis entry in standardized coding workflows.
What it does not mean
- A code alone does not explain severity, treatment plan, or outcome.
- A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
Code hierarchy
chapter
4Endocrine, nutritional and metabolic diseases (E00-E89)
block
E20-E35Disorders of other endocrine glands
category
E31Polyglandular dysfunction
currentE31
Where you may see this code
You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.
Related specialists
EndocrinologistGeneral Physician
Related codes
Sibling codes
Coverage-related procedures and services
CPT 81225high
CYP2C19 (CYTOCHROME P450, FAMILY 2, SUBFAMILY C, POLYPEPTIDE 19) (EG, DRUG METABOLISM), GENE ANALYSIS, COMMON VARIANTS (EG, *2, *3, *4, *8, *17)
Source: CMS coverage guidance
CPT 81418high
DRUG METABOLISM (EG, PHARMACOGENOMICS) GENOMIC SEQUENCE ANALYSIS PANEL, MUST INCLUDE TESTING OF AT LEAST 6 GENES, INCLUDING CYP2C19, CYP2D6, AND CYP2D6 DUPLICATION/DELETION ANALYSIS
Source: CMS coverage guidance
CPT 0349Uhigh
DRUG METABOLISM OR PROCESSING (MULTIPLE CONDITIONS), WHOLE BLOOD OR BUCCAL SPECIMEN, DNA ANALYSIS, 27 GENE REPORT, WITH VARIANT ANALYSIS, INCLUDING REPORTED PHENOTYPES AND IMPACTED GENE-DRUG INTERACTIONS
Source: CMS coverage guidance
CPT 0423Uhigh
PSYCHIATRY (EG, DEPRESSION, ANXIETY), GENOMIC ANALYSIS PANEL, INCLUDING VARIANT ANALYSIS OF 26 GENES, BUCCAL SWAB, REPORT INCLUDING METABOLIZER STATUS AND RISK OF DRUG TOXICITY BY CONDITION
Source: CMS coverage guidance
CPT 0434Uhigh
DRUG METABOLISM (ADVERSE DRUG REACTIONS AND DRUG RESPONSE), GENOMIC ANALYSIS PANEL, VARIANT ANALYSIS OF 25 GENES WITH REPORTED PHENOTYPES
Source: CMS coverage guidance
CPT 0347Uhigh
DRUG METABOLISM OR PROCESSING (MULTIPLE CONDITIONS), WHOLE BLOOD OR BUCCAL SPECIMEN, DNA ANALYSIS, 16 GENE REPORT, WITH VARIANT ANALYSIS AND REPORTED PHENOTYPES
Source: CMS coverage guidance
Mapped diagnoses and classifications
SNOMED_CT 1217047007high
Atrophy of multiple endocrine glands
Source: SNOMED International ICD-10 map
SNOMED_CT 111544009high
Combination of endocrine dysfunction
Source: SNOMED International ICD-10 map
SNOMED_CT 1217057008high
Deficiency of multiple endocrine glands
Source: SNOMED International ICD-10 map
SNOMED_CT 1217079003high
Dystrophy of multiple endocrine glands
Source: SNOMED International ICD-10 map
SNOMED_CT 442761002high
Hypothalamic-pituitary-gonadal axis dysfunction
Source: SNOMED International ICD-10 map
SNOMED_CT 1217066007high
Sclerosis of multiple endocrine glands
Source: SNOMED International ICD-10 map
Coding guidelines
Compatibility
Legacy and official ICD code match exactly.
Legacy codes
E31.8
Common synonyms
Other polyglandular dysfunction
Frequently asked questions
About this content
This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.