ICD10BillableValid for clinical use

ICD-10 Code F33.1: Major depressive disorder, recurrent, moderate

F33.1 is a billable ICD-10 diagnosis code used to classify Major depressive disorder, recurrent, moderate in medical records and claims. You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records. ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Mental, Behavioral and Neurodevelopmental disorders (F01-F99).

Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026

What is this code?

ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Mental, Behavioral and Neurodevelopmental disorders (F01-F99).

When is it used?

  • May be used when a clinician documents major depressive disorder, recurrent, moderate in a patient's medical record.
  • May appear in hospital records, claims, referrals, and clinical documentation.
  • This code can be used as a clinically usable diagnosis entry in standardized coding workflows.

What it does not mean

  • A code alone does not explain severity, treatment plan, or outcome.
  • A medical code should not be treated as a substitute for a doctor's diagnosis or advice.

Code hierarchy

chapter
5Mental, Behavioral and Neurodevelopmental disorders (F01-F99)
block
F30-F39Mood [affective] disorders
category
F33Major depressive disorder, recurrent
currentF33

Where you may see this code

You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.

Coverage-related procedures and services

CPT 81418high
DRUG METABOLISM (EG, PHARMACOGENOMICS) GENOMIC SEQUENCE ANALYSIS PANEL, MUST INCLUDE TESTING OF AT LEAST 6 GENES, INCLUDING CYP2C19, CYP2D6, AND CYP2D6 DUPLICATION/DELETION ANALYSIS
Source: CMS coverage guidance
CPT 0349Uhigh
DRUG METABOLISM OR PROCESSING (MULTIPLE CONDITIONS), WHOLE BLOOD OR BUCCAL SPECIMEN, DNA ANALYSIS, 27 GENE REPORT, WITH VARIANT ANALYSIS, INCLUDING REPORTED PHENOTYPES AND IMPACTED GENE-DRUG INTERACTIONS
Source: CMS coverage guidance
CPT 81226high
CYP2D6 (CYTOCHROME P450, FAMILY 2, SUBFAMILY D, POLYPEPTIDE 6) (EG, DRUG METABOLISM), GENE ANALYSIS, COMMON VARIANTS (EG, *2, *3, *4, *5, *6, *9, *10, *17, *19, *29, *35, *41, *1XN, *2XN, *4XN)
Source: CMS coverage guidance
CPT 90847high
FAMILY PSYCHOTHERAPY (CONJOINT PSYCHOTHERAPY) (WITH PATIENT PRESENT), 50 MINUTES
Source: CMS coverage guidance
CPT 90846high
FAMILY PSYCHOTHERAPY (WITHOUT THE PATIENT PRESENT), 50 MINUTES
Source: CMS coverage guidance
CPT 90785high
INTERACTIVE COMPLEXITY (LIST SEPARATELY IN ADDITION TO THE CODE FOR PRIMARY PROCEDURE)
Source: CMS coverage guidance

Coding guidelines

Compatibility

Legacy and official ICD code match exactly.
Legacy codes
F33.1

Common synonyms

Major depressive disorder, recurrent, moderate

Frequently asked questions

Code details

CodeF33.1
SystemICD10
Display nameMajor depressive disorder, recurrent, moderate
ChapterMental, Behavioral and Neurodevelopmental disorders (F01-F99)
BlockMood [affective] disorders

Flags

BillableYes
Valid clinical useYes

Source

SourceICD-10
Version2026-annual
Releaseannual
Year2026

Index terms

Matched terms
Disorder(of)

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.

ICD-10 Code F33.1 for Major depressive disorder, recurrent, moderate | HealthAssure