When is ICD-10 code I25.81 used?

Doctors, hospitals, and insurers may use ICD-10 code I25.81 when recording atherosclerosis of other coronary vessels without angina pectoris in a standardized format. This entry may also act as a broader category that points toward more specific child codes.

Does ICD-10 code I25.81 confirm a diagnosis?

No. A code helps standardize documentation and claims, but it should not be read as a substitute for a clinician's full assessment.

ICD10

ICD-10 Code I25.81: Atherosclerosis of other coronary vessels without angina pectoris

Name: ICD-10 Code I25.81: Atherosclerosis of other coronary vessels without angina pectoris
Creator: HealthAssure Clinical Team
Published: 2026-05-21T06:12:44.559Z

I25.81 is an ICD-10 diagnosis entry used to group records related to Atherosclerosis of other coronary vessels without angina pectoris. You may see this entry in coding references, medical records, or claims workflows when a broader diagnosis category is being reviewed before a more specific code is chosen. ICD-10 entries help standardize how diagnoses are organized for coding, reporting, analytics, and documentation. This code sits within the broader ICD-10 area for Diseases of the circulatory system (I00-I99).

Reviewed by HealthAssure Clinical TeamUpdated 21 May 2026

What is this code?

ICD-10 entries help standardize how diagnoses are organized for coding, reporting, analytics, and documentation. This code sits within the broader ICD-10 area for Diseases of the circulatory system (I00-I99).

When is it used?

May be used when a clinician documents atherosclerosis of other coronary vessels without angina pectoris in a patient's medical record.
May appear in hospital records, claims, referrals, and clinical documentation.
This code may act more like a grouping or parent code, so a more specific child code may be used in final documentation when available.

What it does not mean

A code alone does not explain severity, treatment plan, or outcome.
A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
This entry may represent a broader category rather than the most specific billable code.

Code hierarchy

chapter

9Diseases of the circulatory system (I00-I99)

block

I20-I25Ischemic heart diseases

Official coding notes

Applicable to

code, if applicable, to identify:
coronary atherosclerosis due to calcified coronary lesion (I25.84)
coronary atherosclerosis due to lipid rich plaque (I25.83)

Excludes2 (may code together if documented)

atherosclerotic heart disease of native coronary artery without angina pectoris (I25.10)

Use additional code

code, if applicable, to identify:
coronary atherosclerosis due to calcified coronary lesion (I25.84)
coronary atherosclerosis due to lipid rich plaque (I25.83)

Where you may see this code

You may see this entry in coding references, medical records, or claims workflows when a broader diagnosis category is being reviewed before a more specific code is chosen.

Related specialists

CardiologistGeneral Physician

Sibling codes

I25.82Chronic total occlusion of coronary arterybillable I25.83Coronary atherosclerosis due to lipid rich plaquebillable I25.84Coronary atherosclerosis due to calcified coronary lesionbillable I25.85Chronic coronary microvascular dysfunctionbillable I25.89Other forms of chronic ischemic heart diseasebillable

Coding guidelines

Common synonyms

Atherosclerosis of other coronary vessels without angina pectoris

Frequently asked questions

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.