ICD10BillableValid for clinical use

ICD-10 Code J45.41: Moderate persistent asthma with (acute) exacerbation

J45.41 is a billable ICD-10 diagnosis code used to classify Moderate persistent asthma with (acute) exacerbation in medical records and claims. You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records. ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Diseases of the respiratory system (J00-J99).

Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026

What is this code?

ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Diseases of the respiratory system (J00-J99).

When is it used?

  • May be used when a clinician documents moderate persistent asthma with (acute) exacerbation in a patient's medical record.
  • May appear in hospital records, claims, referrals, and clinical documentation.
  • This code can be used as a clinically usable diagnosis entry in standardized coding workflows.

What it does not mean

  • A code alone does not explain severity, treatment plan, or outcome.
  • A medical code should not be treated as a substitute for a doctor's diagnosis or advice.

Code hierarchy

chapter
10Diseases of the respiratory system (J00-J99)
block
J40-J4AChronic lower respiratory diseases
category
J45Asthma
category
J45.4Moderate persistent asthma
currentJ45.4

Where you may see this code

You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.

Related specialists

PulmonologistGeneral Physician

Related tests

Spirometry
Commonly used to assess airflow limitation in asthma care.
Peak expiratory flow
May help monitor airflow changes over time in asthma follow-up.

Related procedures

Nebulizer treatment
May appear in symptomatic asthma care pathways.
Pulmonary rehabilitation counseling
May be relevant in selected chronic respiratory management pathways.

Coverage-related procedures and services

CPT 86003high
ALLERGEN SPECIFIC IGE; QUANTITATIVE OR SEMIQUANTITATIVE, CRUDE ALLERGEN EXTRACT, EACH
Source: CMS coverage guidance
CPT 87631high
INFECTIOUS AGENT DETECTION BY NUCLEIC ACID (DNA OR RNA); RESPIRATORY VIRUS (EG, ADENOVIRUS, INFLUENZA VIRUS, CORONAVIRUS, METAPNEUMOVIRUS, PARAINFLUENZA VIRUS, RESPIRATORY SYNCYTIAL VIRUS, RHINOVIRUS), INCLUDES MULTIPLEX REVERSE TRANSCRIPTION, WHEN PERFORMED, AND MULTIPLEX AMPLIFIED PROBE TECHNIQUE, MULTIPLE TYPES OR SUBTYPES, 3-5 TARGETS
Source: CMS coverage guidance
CPT 87636high
INFECTIOUS AGENT DETECTION BY NUCLEIC ACID (DNA OR RNA); SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2) (CORONAVIRUS DISEASE [COVID-19]) AND INFLUENZA VIRUS TYPES A AND B, MULTIPLEX AMPLIFIED PROBE TECHNIQUE
Source: CMS coverage guidance
CPT 87637high
INFECTIOUS AGENT DETECTION BY NUCLEIC ACID (DNA OR RNA); SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2) (CORONAVIRUS DISEASE [COVID-19]), INFLUENZA VIRUS TYPES A AND B, AND RESPIRATORY SYNCYTIAL VIRUS, MULTIPLEX AMPLIFIED PROBE TECHNIQUE
Source: CMS coverage guidance
CPT 86008high
ALLERGEN SPECIFIC IGE; QUANTITATIVE OR SEMIQUANTITATIVE, RECOMBINANT OR PURIFIED COMPONENT, EACH
Source: CMS coverage guidance
CPT 95018high
ALLERGY TESTING, ANY COMBINATION OF PERCUTANEOUS (SCRATCH, PUNCTURE, PRICK) AND INTRACUTANEOUS (INTRADERMAL), SEQUENTIAL AND INCREMENTAL, WITH DRUGS OR BIOLOGICALS, IMMEDIATE TYPE REACTION, INCLUDING TEST INTERPRETATION AND REPORT, SPECIFY NUMBER OF TESTS
Source: CMS coverage guidance

Coding guidelines

Common synonyms

Moderate persistent asthma with (acute) exacerbationModerate persistent asthma withModerate persistent asthma with acute exacerbation

Frequently asked questions

Code details

CodeJ45.41
SystemICD10
Display nameModerate persistent asthma with (acute) exacerbation
ChapterDiseases of the respiratory system (J00-J99)
BlockChronic lower respiratory diseases

Flags

BillableYes
Valid clinical useYes

Source

SourceICD-10
Version2026-annual
Releaseannual
Year2026

Index terms

Matched terms
Asthma, asthmatic(bronchial) (catarrh) (spasmodic)Asthma, asthmatic(bronchial) (catarrh) (spasmodic)

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.

ICD-10 Code J45.41 for Moderate persistent asthma with (acute) exacerbation | HealthAssure