ICD-10 Code M35.81: Multisystem inflammatory syndrome
M35.81 is a billable ICD-10 diagnosis code used to classify Multisystem inflammatory syndrome in medical records and claims. You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records. ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Diseases of the musculoskeletal system and connective tissue (M00-M99).
What is this code?
ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Diseases of the musculoskeletal system and connective tissue (M00-M99).
When is it used?
- May be used when a clinician documents multisystem inflammatory syndrome in a patient's medical record.
- May appear in hospital records, claims, referrals, and clinical documentation.
- This code can be used as a clinically usable diagnosis entry in standardized coding workflows.
What it does not mean
- A code alone does not explain severity, treatment plan, or outcome.
- A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
Code hierarchy
Official coding notes
- MIS-A
- MIS-C
- Multisystem inflammatory syndrome in adults
- Multisystem inflammatory syndrome in children
- Pediatric inflammatory multisystem syndrome
- PIMS
- code, if applicable, for:
- exposure to COVID-19 or SARS-CoV-2 infection (Z20.822)
- personal history of COVID-19 (Z86.16)
- post COVID-19 condition (U09.9)
- , if applicable, COVID-19 (U07.1)
- , if applicable, COVID-19 (U07.1)
- code, if applicable, for:
- exposure to COVID-19 or SARS-CoV-2 infection (Z20.822)
- personal history of COVID-19 (Z86.16)
- post COVID-19 condition (U09.9)
- any associated complications such as:
- acute hepatic failure (K72.0-)
- acute kidney failure (N17.-)
- acute myocarditis (I40.-)
- acute respiratory distress syndrome (J80)
- cardiac arrhythmia (I47-I49.-)
- pneumonia due to COVID-19 (J12.82)
- severe sepsis (R65.2-)
- viral cardiomyopathy (B33.24)
- viral pericarditis (B33.23)
Where you may see this code
You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.
Related specialists
Coverage-related procedures and services
Coding guidelines
Common synonyms
Frequently asked questions
About this content
This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.