What does ICD-10 code O99.322 mean?

ICD-10 code O99.322 is the standardized code used for drug use complicating pregnancy, second trimester in medical records and coding systems.

When is ICD-10 code O99.322 used?

Doctors, hospitals, and insurers may use ICD-10 code O99.322 when recording drug use complicating pregnancy, second trimester in a standardized format.

Does ICD-10 code O99.322 confirm a diagnosis?

No. A code helps standardize documentation and claims, but it should not be read as a substitute for a clinician's full assessment.

ICD10BillableValid for clinical use

ICD-10 Code O99.322: Drug use complicating pregnancy, second trimester

Name: ICD-10 Code O99.322: Drug use complicating pregnancy, second trimester
Creator: HealthAssure Clinical Team
Published: 2026-05-26T14:50:16.732Z

O99.322 is a billable ICD-10 diagnosis code used to classify Drug use complicating pregnancy, second trimester in medical records and claims. You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records. ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Pregnancy, childbirth and the puerperium (O00-O9A).

Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026

What is this code?

ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Pregnancy, childbirth and the puerperium (O00-O9A).

When is it used?

May be used when a clinician documents drug use complicating pregnancy, second trimester in a patient's medical record.
May appear in hospital records, claims, referrals, and clinical documentation.
This code can be used as a clinically usable diagnosis entry in standardized coding workflows.

What it does not mean

A code alone does not explain severity, treatment plan, or outcome.
A medical code should not be treated as a substitute for a doctor's diagnosis or advice.

Code hierarchy

chapter

15Pregnancy, childbirth and the puerperium (O00-O9A)

block

O94-O9AOther obstetric conditions, not elsewhere classified

Where you may see this code

You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.

Related specialists

ObstetricianGynecologist

Related procedures

Obstetric ultrasound

May appear in pregnancy follow-up pathways when maternal diseases complicate pregnancy and fetal well-being is monitored.

Fetal nonstress testing

May be used in selected higher-risk pregnancy monitoring pathways.

Sibling codes

O99.320Drug use complicating pregnancy, unspecified trimesterbillable O99.321Drug use complicating pregnancy, first trimesterbillable O99.323Drug use complicating pregnancy, third trimesterbillable O99.324Drug use complicating childbirthbillable O99.325Drug use complicating the puerperiumbillable

Coverage-related procedures and services

CPT 83735high

MAGNESIUM

Source: CMS coverage guidance

Coding guidelines

Common synonyms

Drug use complicating pregnancy, second trimester

Frequently asked questions

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.