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ICD-10 Code R52: Pain, unspecified

R52 is a billable ICD-10 diagnosis code used to classify Pain, unspecified in medical records and claims. You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records. ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99).

Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026

What is this code?

ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99).

When is it used?

  • May be used when a clinician documents pain, unspecified in a patient's medical record.
  • May appear in hospital records, claims, referrals, and clinical documentation.
  • This code can be used as a clinically usable diagnosis entry in standardized coding workflows.

What it does not mean

  • A code alone does not explain severity, treatment plan, or outcome.
  • A medical code should not be treated as a substitute for a doctor's diagnosis or advice.

Code hierarchy

chapter
18Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)
block
R50-R69General symptoms and signs
currentR50-R69

Official coding notes

Inclusion terms
  • Acute pain NOS
  • Generalized pain NOS
  • Pain NOS
Excludes1 (do not code together)
  • acute and chronic pain, not elsewhere classified (G89.-)
  • localized pain, unspecified type - code to pain by site, such as:
  • abdomen pain (R10.-)
  • back pain (M54.9)
  • breast pain (N64.4)
  • chest pain (R07.1-R07.9)
  • ear pain (H92.0-)
  • eye pain (H57.1)
  • headache (R51.9)
  • joint pain (M25.5-)
  • limb pain (M79.6-)
  • lumbar region pain (M54.5-)
  • pelvic and perineal pain (R10.2-)
  • shoulder pain (M25.51-)
  • spine pain (M54.-)
  • throat pain (R07.0)
  • tongue pain (K14.6)
  • tooth pain (K08.8)
  • renal colic (N23)
  • pain disorders exclusively related to psychological factors (F45.41)

Where you may see this code

You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.

Related specialists

General Physician

Coverage-related procedures and services

CPT 81226high
CYP2D6 (CYTOCHROME P450, FAMILY 2, SUBFAMILY D, POLYPEPTIDE 6) (EG, DRUG METABOLISM), GENE ANALYSIS, COMMON VARIANTS (EG, *2, *3, *4, *5, *6, *9, *10, *17, *19, *29, *35, *41, *1XN, *2XN, *4XN)
Source: CMS coverage guidance
CPT 81418high
DRUG METABOLISM (EG, PHARMACOGENOMICS) GENOMIC SEQUENCE ANALYSIS PANEL, MUST INCLUDE TESTING OF AT LEAST 6 GENES, INCLUDING CYP2C19, CYP2D6, AND CYP2D6 DUPLICATION/DELETION ANALYSIS
Source: CMS coverage guidance
CPT 0349Uhigh
DRUG METABOLISM OR PROCESSING (MULTIPLE CONDITIONS), WHOLE BLOOD OR BUCCAL SPECIMEN, DNA ANALYSIS, 27 GENE REPORT, WITH VARIANT ANALYSIS, INCLUDING REPORTED PHENOTYPES AND IMPACTED GENE-DRUG INTERACTIONS
Source: CMS coverage guidance
CPT 0423Uhigh
PSYCHIATRY (EG, DEPRESSION, ANXIETY), GENOMIC ANALYSIS PANEL, INCLUDING VARIANT ANALYSIS OF 26 GENES, BUCCAL SWAB, REPORT INCLUDING METABOLIZER STATUS AND RISK OF DRUG TOXICITY BY CONDITION
Source: CMS coverage guidance
CPT 0070Uhigh
CYP2D6 (CYTOCHROME P450, FAMILY 2, SUBFAMILY D, POLYPEPTIDE 6) (EG, DRUG METABOLISM) GENE ANALYSIS, COMMON AND SELECT RARE VARIANTS (IE, *2, *3, *4, *4N, *5, *6, *7, *8, *9, *10, *11, *12, *13, *14A, *14B, *15, *17, *29, *35, *36, *41, *57, *61, *63, *68, *83, *XN)
Source: CMS coverage guidance
CPT 0071Uhigh
CYP2D6 (CYTOCHROME P450, FAMILY 2, SUBFAMILY D, POLYPEPTIDE 6) (EG, DRUG METABOLISM) GENE ANALYSIS, FULL GENE SEQUENCE (LIST SEPARATELY IN ADDITION TO CODE FOR PRIMARY PROCEDURE)
Source: CMS coverage guidance

Coding guidelines

Compatibility

Legacy and official ICD code match exactly.
Legacy codes
R52

Common synonyms

Pain, unspecifiedPain

Frequently asked questions

Code details

CodeR52
SystemICD10
Display namePain, unspecified
ChapterSymptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)
BlockGeneral symptoms and signs

Flags

BillableYes
Valid clinical useYes

Source

SourceICD-10
Version2026-annual
Releaseannual
Year2026

Index terms

Matched terms
Pain(s)Pain(s)Pain(s)
See also
Painful

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.

ICD-10 Code R52 for Pain, unspecified | HealthAssure