When is ICD-10 code R65.1 used?

Doctors, hospitals, and insurers may use ICD-10 code R65.1 when recording systemic inflammatory response syndrome (sirs) of non-infectious origin in a standardized format. This entry may also act as a broader category that points toward more specific child codes.

Does ICD-10 code R65.1 confirm a diagnosis?

No. A code helps standardize documentation and claims, but it should not be read as a substitute for a clinician's full assessment.

ICD10

ICD-10 Code R65.1: Systemic inflammatory response syndrome (SIRS) of non-infectious origin

Name: ICD-10 Code R65.1: Systemic inflammatory response syndrome (SIRS) of non-infectious origin
Creator: HealthAssure Clinical Team
Published: 2026-05-21T06:30:42.520Z

R65.1 is an ICD-10 diagnosis entry used to group records related to Systemic inflammatory response syndrome (SIRS) of non-infectious origin. You may see this entry in coding references, medical records, or claims workflows when a broader diagnosis category is being reviewed before a more specific code is chosen. ICD-10 entries help standardize how diagnoses are organized for coding, reporting, analytics, and documentation. This code sits within the broader ICD-10 area for Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99).

Reviewed by HealthAssure Clinical TeamUpdated 21 May 2026

What is this code?

ICD-10 entries help standardize how diagnoses are organized for coding, reporting, analytics, and documentation. This code sits within the broader ICD-10 area for Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99).

When is it used?

May be used when a clinician documents systemic inflammatory response syndrome (sirs) of non-infectious origin in a patient's medical record.
May appear in hospital records, claims, referrals, and clinical documentation.
This code may act more like a grouping or parent code, so a more specific child code may be used in final documentation when available.

What it does not mean

A code alone does not explain severity, treatment plan, or outcome.
A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
This entry may represent a broader category rather than the most specific billable code.

Code hierarchy

chapter

18Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)

block

R50-R69General symptoms and signs

Official coding notes

Applicable to

underlying condition, such as:
heatstroke (T67.0-)
injury and trauma (S00-T88)

Excludes1 (do not code together)

sepsis- code to infection
severe sepsis (R65.2)

Code first

underlying condition, such as:
heatstroke (T67.0-)
injury and trauma (S00-T88)

Where you may see this code

You may see this entry in coding references, medical records, or claims workflows when a broader diagnosis category is being reviewed before a more specific code is chosen.

Related specialists

General Physician

Sibling codes

R65.2Severe sepsis

Coding guidelines

Compatibility

Legacy code aligns to an official FY 2026 category. Frontend should resolve to the official category page and surface the billable child codes.

Legacy codes

R65.1

Replacement codes

R65.10 — Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunctionR65.11 — Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

Common synonyms

Systemic inflammatory response syndrome (SIRS) of non-infectious originSystemic inflammatory response syndromeSystemic inflammatory response syndrome SIRS of non-infectious origin

Frequently asked questions

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.