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ICD-10 Code T46: Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system

T46 is an ICD-10 diagnosis entry used to group records related to Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system. You may see this entry in coding references, medical records, or claims workflows when a broader diagnosis category is being reviewed before a more specific code is chosen. ICD-10 entries help standardize how diagnoses are organized for coding, reporting, analytics, and documentation. This code sits within the broader ICD-10 area for Injury, poisoning and certain other consequences of external causes (S00-T88).

Reviewed by HealthAssure Clinical TeamUpdated 21 May 2026

What is this code?

ICD-10 entries help standardize how diagnoses are organized for coding, reporting, analytics, and documentation. This code sits within the broader ICD-10 area for Injury, poisoning and certain other consequences of external causes (S00-T88).

When is it used?

  • May be used when a clinician documents poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system in a patient's medical record.
  • May appear in hospital records, claims, referrals, and clinical documentation.
  • This code may act more like a grouping or parent code, so a more specific child code may be used in final documentation when available.

What it does not mean

  • A code alone does not explain severity, treatment plan, or outcome.
  • A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
  • This entry may represent a broader category rather than the most specific billable code.

Code hierarchy

chapter
19Injury, poisoning and certain other consequences of external causes (S00-T88)
block
T07-T88Injury, poisoning and certain other consequences of external causes
block
T36-T50Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances
currentT36-T50

Official coding notes

Excludes1 (do not code together)
  • poisoning by, adverse effect of and underdosing of metaraminol (T44.4)
7th character notes
  • The appropriate 7th character is to be added to each code from category T46
  • initial encounter
  • subsequent encounter
  • sequela

Where you may see this code

You may see this entry in coding references, medical records, or claims workflows when a broader diagnosis category is being reviewed before a more specific code is chosen.

Related specialists

Emergency Medicine SpecialistOrthopedic SpecialistCardiologist

Related codes

T36Poisoning by, adverse effect of and underdosing of systemic antibioticscategoryT37Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasiticscategoryT38Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classifiedcategoryT39Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumaticscategoryT40Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens]categoryT41Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gasescategoryT42Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugscategoryT43Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classifiedcategoryT44Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous systemcategoryT45Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classifiedcategoryT47Poisoning by, adverse effect of and underdosing of agents primarily affecting the gastrointestinal systemcategoryT48Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory systemcategory

Sibling codes

T36Poisoning by, adverse effect of and underdosing of systemic antibioticsT37Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasiticsT38Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classifiedT39Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumaticsT40Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens]T41Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gasesT42Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugsT43Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classifiedT44Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous systemT45Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classifiedT47Poisoning by, adverse effect of and underdosing of agents primarily affecting the gastrointestinal systemT48Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory systemT49Poisoning by, adverse effect of and underdosing of topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinorlaryngological and dental drugsT50Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances

Coding guidelines

Compatibility

Legacy code aligns to an official FY 2026 category. Frontend should resolve to the official category page and surface the billable child codes.
Legacy codes
T46

Common synonyms

Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system

Frequently asked questions

Code details

CodeT46
SystemICD10
Display namePoisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system
ChapterInjury, poisoning and certain other consequences of external causes (S00-T88)
BlockPoisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances

Flags

BillableNo
Valid clinical useNo

Source

SourceICD-10
Version2026-annual
Releaseannual
Year2026

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.

ICD-10 Code T46 for Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system | HealthAssure