ICD10

ICD-10 Code T80.5: Anaphylactic reaction due to serum

T80.5 is an ICD-10 diagnosis entry used to group records related to Anaphylactic reaction due to serum. You may see this entry in coding references, medical records, or claims workflows when a broader diagnosis category is being reviewed before a more specific code is chosen. ICD-10 entries help standardize how diagnoses are organized for coding, reporting, analytics, and documentation. This code sits within the broader ICD-10 area for Injury, poisoning and certain other consequences of external causes (S00-T88).

Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026

What is this code?

ICD-10 entries help standardize how diagnoses are organized for coding, reporting, analytics, and documentation. This code sits within the broader ICD-10 area for Injury, poisoning and certain other consequences of external causes (S00-T88).

When is it used?

  • May be used when a clinician documents anaphylactic reaction due to serum in a patient's medical record.
  • May appear in hospital records, claims, referrals, and clinical documentation.
  • This code may act more like a grouping or parent code, so a more specific child code may be used in final documentation when available.

What it does not mean

  • A code alone does not explain severity, treatment plan, or outcome.
  • A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
  • This entry may represent a broader category rather than the most specific billable code.

Code hierarchy

chapter
19Injury, poisoning and certain other consequences of external causes (S00-T88)
block
T07-T88Injury, poisoning and certain other consequences of external causes
block
T80-T88Complications of surgical and medical care, not elsewhere classified
category
T80Complications following infusion, transfusion and therapeutic injection
currentT80

Official coding notes

Inclusion terms
  • Allergic shock due to serum
  • Anaphylactic shock due to serum
  • Anaphylactoid reaction due to serum
  • Anaphylaxis due to serum
Excludes1 (do not code together)
  • ABO incompatibility reaction due to transfusion of blood or blood products (T80.3-)
  • allergic reaction or shock NOS (T78.2)
  • anaphylactic reaction or shock NOS (T78.2)
  • anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6)
  • other serum reaction (T80.6-)

Where you may see this code

You may see this entry in coding references, medical records, or claims workflows when a broader diagnosis category is being reviewed before a more specific code is chosen.

Related specialists

Emergency Medicine SpecialistOrthopedic Specialist

Coding guidelines

Compatibility

Legacy code aligns to an official FY 2026 category. Frontend should resolve to the official category page and surface the billable child codes.
Legacy codes
T80.5
Replacement codes
T80.51 — Anaphylactic reaction due to administration of blood and blood productsT80.52 — Anaphylactic reaction due to vaccinationT80.59 — Anaphylactic reaction due to other serum

Common synonyms

Anaphylactic reaction due to serum

Frequently asked questions

Code details

CodeT80.5
SystemICD10
Display nameAnaphylactic reaction due to serum
ChapterInjury, poisoning and certain other consequences of external causes (S00-T88)
BlockComplications of surgical and medical care, not elsewhere classified

Flags

BillableNo
Valid clinical useNo

Source

SourceICD-10
Version2026-annual
Releaseannual
Year2026

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.