LOINCActiveObservation

LOINC Code 47222-5: Trisomy 21 risk based on maternal age+Alpha-1-Fetoprotein+Choriogonadotropin+Estriol.unconjugated Qn (fetus)

47222-5 is a LOINC code used to identify Trisomy 21 risk based on maternal age+Alpha-1-Fetoprotein+Choriogonadotropin+Estriol.unconjugated Qn (fetus) in laboratory and clinical observation data. You may see this code in lab systems, lab reports, EHR exports, interoperability feeds, or other structured clinical data exchanges. LOINC codes identify tests, measurements, observations, survey items, and clinical questions in a standardized way. It is associated with the component Trisomy 21 risk based on maternal age + Alpha-1-Fetoprotein + Choriogonadotropin + Estriol.unconjugated. It is commonly used with the system or sample type ^Fetus.

Reviewed by HealthAssure Clinical TeamUpdated 21 May 2026

What is this code?

LOINC codes identify tests, measurements, observations, survey items, and clinical questions in a standardized way. It is associated with the component Trisomy 21 risk based on maternal age + Alpha-1-Fetoprotein + Choriogonadotropin + Estriol.unconjugated. It is commonly used with the system or sample type ^Fetus.

When is it used?

  • Used in lab systems, EHRs, and clinical data exchange.
  • May identify a test, observation, survey item, or clinical document request rather than a diagnosis.
  • Status: ACTIVE
  • Order vs observation: Observation

What it does not mean

  • The code identifies the observation or test, not the actual result.

Key facts

  • Trisomy 21 risk based on maternal age+Alpha-1-Fetoprotein+Choriogonadotropin+Estriol.unconjugated [Likelihood] in Fetus
  • Trisomy 21 risk based on maternal age + Alpha-1-Fetoprotein + Choriogonadotropin + Estriol.unconjugated
  • A1; AFP; Alfa; Alpha fetoprotein; Alphafetoprotein; CG; Chemistry; Choriogonadotropins total; Chorionic gonadotropin; Down syndrome; Downs; Down's syndrome; ds; E3; Estriol free; Fetal; Feto; Gyn; Gynecology; HCG; Human chorionic gonadotropin; i; OB; ObGyn; Obstetrics; Point in time; QNT; Quan; Quant; Quantitative; Random; Risk; Ts; Ts 21 risk; Ts 21risk-age; Ts 21risk-age+AFP+HCG+uE3; Tumor marker; u Estriol; uE3; Uncnj; Unconj; Unconjug; Unconjugat

Where you may see this code

You may see this code in lab systems, lab reports, EHR exports, interoperability feeds, or other structured clinical data exchanges.

Common synonyms

Trisomy 21 risk based on maternal age+Alpha-1-Fetoprotein+Choriogonadotropin+Estriol.unconjugated Qn (fetus)Trisomy 21 risk based on maternal age+Alpha-1-Fetoprotein+Choriogonadotropin+Estriol.unconjugated [Likelihood] in FetusTs 21risk-age+AFP+HCG+uE3 FetusTrisomy 21 risk based on maternal age + Alpha-1-Fetoprotein + Choriogonadotropin + Estriol.unconjugatedCHEMFetal Trisomy 21 risk Based on maternal Age+Alpha-1-Fetoprotein+Choriogonadotropin+Estriol.unconjugatedLikelihood

Frequently asked questions

Code details

Code47222-5
SystemLOINC
Display nameTrisomy 21 risk based on maternal age+Alpha-1-Fetoprotein+Choriogonadotropin+Estriol.unconjugated Qn (fetus)
DescriptionTrisomy 21 risk based on maternal age + Alpha-1-Fetoprotein + Choriogonadotropin + Estriol.unconjugated
Short nameTs 21risk-age+AFP+HCG+uE3 Fetus
ComponentTrisomy 21 risk based on maternal age + Alpha-1-Fetoprotein + Choriogonadotropin + Estriol.unconjugated
PropertyLikelihood
TimingPt
System (specimen)^Fetus
ScaleQn
ClassCHEM
StatusACTIVE
Order/ObservationObservation

Flags

BillableNo
Valid clinical useNo

Source

SourceLOINC
Version2.82
Releasemain
First released2.19
Last changed2.73

Consumer names

Fetal Trisomy 21 risk Based on maternal Age+Alpha-1-Fetoprotein+Choriogonadotropin+Estriol.unconjugated

Part names

Trisomy 21 risk based on maternal age + Alpha-1-Fetoprotein + Choriogonadotropin + Estriol.unconjugatedLikelihoodPt^FetusQnTrisomy 21 risk based on maternal age+Alpha-1-Fetoprotein+Choriogonadotropin+Estriol.unconjugatedPoint in time (spot)

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from LOINC. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.