LOINC Code 72312-2: t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript Molgen (Bld/Tiss) [# ratio]

What is this code?

LOINC codes identify tests, measurements, observations, survey items, and clinical questions in a standardized way. It is associated with the component t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript. It is commonly used with the system or sample type Bld/Tiss.

When is it used?

• Used in lab systems, EHRs, and clinical data exchange.
• May identify a test, observation, survey item, or clinical document request rather than a diagnosis.
• Status: ACTIVE
• Order vs observation: Both
• Method: Molgen

What it does not mean

• The code identifies the observation or test, not the actual result.

Key facts

• t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method
• t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript
• A translocation involving chromosomes 1 and 19, t(1;19)(q23;p13), results in a fused transcript between TCF3 (formerly E2A) and PBX1 (formerly prl) genes. The TCF3-PBX1 fusion gene is found in approximately 3% of childhood and adult precursor-B acute lymphoblastic leukemia (ALL). This code is based on, but not limited to, Ispogen's E2A-PBX1 FusionQuant® kit, which uses real-time Quantitative RQ-PCR to quantify the expression level of specific TCF3(E2A)-PBX1 fusion gene transcripts relative to a control gene transcript (e.g. ABL1). From the manufacturer's website (2012), "Quantification of E2A-PBX1 fusion gene transcripts has been standardized in the EAC (Europe Against Cancer) program [Gabert J et al. Leukemia. 2003, Beillard E et al. Leukemia. 2003], and IPSOGEN FusionQuant® kits use this validated technology to calibrate and normalize RQ-PCR results."
• ABL; ABL1; ABL1 transcript; Acute lymphoblastic leukaemia; Acute lymphoblastic leukemia; Acute myeloid leukemia; ALL; AML; Blood; control gene; DNA; E2A Immunoglobulin enhancer binding factors E12/E47; gene fusion; gene translocation; Genetics; Heredity; Heritable; i; Immunoglobulin transcription factor 1; Inherited; ITF1; Molecular genetics; Molecular pathology; MOLPATH; MOLPATH.TRANSLOCATION; Non-Hodgkin lymphoma; Number ratio; PBXP1; PCR; Point in time; Pre-B cell leukemia transcription factor-1; QNT; Quan; Quant; Quantitative; Random; RNA; T prime; t(1;19)(PBX1,TCF3); Tissue; Tissue, unspecified; Transcription factor 3; translocation; WB; Whole blood; Whole blood or Tissue

Where you may see this code

You may see this code in lab systems, lab reports, EHR exports, interoperability feeds, or other structured clinical data exchanges.

Common synonyms

Frequently asked questions