LOINC Code 74041-5: t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusion transcript/control transcript.reduction to 0.1% post treatment Molgen Ql (Bld/Tiss)

What is this code?

LOINC codes identify tests, measurements, observations, survey items, and clinical questions in a standardized way. It is associated with the component t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusion transcript/control transcript.reduction to 0.1%^post treatment. It is commonly used with the system or sample type Bld/Tiss.

When is it used?

• Used in lab systems, EHRs, and clinical data exchange.
• May identify a test, observation, survey item, or clinical document request rather than a diagnosis.
• Status: ACTIVE
• Order vs observation: Both
• Method: Molgen

What it does not mean

• The code identifies the observation or test, not the actual result.

Key facts

• BCR-ABL1 p210 Major Molecular Response (MMR) [Presence] in Blood or Tissue by Molecular genetics method --post treatment
• t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusion transcript/control transcript.reduction to 0.1%^post treatment
• Patient's with CML and undergoing tyrosine kinase inhibitor (TKI) therapy may be monitored to assess their treatment response (reduction in BCR-ABL1 transcripts) to therapy. A major molecular response (MMR) occurs when the ratio of BCR-ABL1 transcripts to control gene is less than or equal to 0.1% according to the International Scale (IS), a consensus standardized measurement scale intended to allow direct comparison of BCR-ABL1 major breakpoint (b2a2, b3a2) RNA levels in any laboratory adopting its use. Studies have demonstrated that achieving MMR within 18 months following TKI therapy is associated with a minimal risk of progression at 84 months (NCCN Guidelines CML, 2013).
• ABL; After; ALL; bcr/abl; BCR1; bcr-abl1; Blood; Breakpoint cluster region; Chronic myeloid leukemia; CML; D22S11; D22S662; DNA; e13a2; e14a2; gene fusion; gene translocation; Genetics; Hematology; Heme; Heredity; Heritable; Inherited; JTK7; major breakpoints; Mbr; Mcr; minor breakpoints; Molecular genetics; Molecular pathology; MOLPATH; Ordinal; p Tx; p150; p210; PCR; Ph chromosome; Philadelphia chromosome; PHL; Point in time; PR; PST; QL; Qual; Qualitative; Random; RNA; Screen; T prime; t(9,22)(ABL1,BCR) gene translocation; t(9,22)(ABL1,BCR) p210 gene translocation; t(9,22)(ABL1,BCR) Translocation; t(9,22)(q34,q11); t(9,22)(q34.1,q11); t(9;22)(ABL1,BCR); t(ABL1,BCR)b2a2; t(ABL1,BCR)p210; Tissue; Tissue, unspecified; translocation; Tx; v-abl Abelson murine leukemia viral oncogene homolog 1; WB; Whole blood; Whole blood or Tissue

Where you may see this code

You may see this code in lab systems, lab reports, EHR exports, interoperability feeds, or other structured clinical data exchanges.

Common synonyms

Frequently asked questions