LOINC Code 77927-2: Cortisol 5 Min post Unsp challenge [Moles/Vol]

What is this code?

LOINC codes identify tests, measurements, observations, survey items, and clinical questions in a standardized way. It is associated with the component Cortisol^5M post XXX challenge. It is commonly used with the system or sample type Ser/Plas.

When is it used?

• Used in lab systems, EHRs, and clinical data exchange.
• May identify a test, observation, survey item, or clinical document request rather than a diagnosis.
• Status: ACTIVE
• Order vs observation: Observation

What it does not mean

• The code identifies the observation or test, not the actual result.

Key facts

• Cortisol [Moles/volume] in Serum or Plasma --5 minutes post XXX challenge
• Cortisol^5M post XXX challenge
• Timed cortisol levels are obtained for adrenocorticotropic hormone challenge tests to assist in diagnosing adrenocortical insufficiency as found in Cushing's syndrome and Addison's disease. There are different types of challenges. ACTH (adrenocorticotropic hormone) stimulation, where cosyntropin (a synthetic form of ACTH) is given, and then blood is sampled for cortisol levels before the bolus, and at specified times after the bolus. The ACTH stimulation directly evaluates adrenal gland function and indirectly evaluates pituitary gland and hypothalamus function. Cortisol levels rise significantly after administration of cosyntropin if the adrenal glands are functioning normally. For the CRH (corticotropin-releasing hormone) stimulation, CRH is given and cortisol and ACTH levels are determined before the injection, at the injection time, and specified times following injection. The CRH stimulation test is used to distinguish Cushings disease from conditions where ACTH is secreted ectopically. For the Dexamethasone suppression (overnight) test (DST), dexamethasone (Decadron) is given and samples for cortisol levels are collected the following morning. The DST differentiates the causes of increased cortisol levels. For the Metyrapone (overnight) stimulation challenge, metyrapone is given with a snack at midnight. Samples for cortisol, 11-deoxycortisol, and ACTH are collected the following morning. The metyrapone stimulation test distinguishes corticotropin-dependent causes (pituitary Cushing's disease and ectopic Cushing's disease) from corticotropin-independent causes (carcinoma of the lung or thyroid) of increased cortisol levels.
• 17-Hydroxycorticosterone; 5M p chal; After; CHEMISTRY.CHALLENGE TESTING; Compound F; Coritsol; Cort; F; hydrocortisone; Level; p chal; Pl; Plasma; Plsm; Point in time; PST; QNT; Quan; Quant; Quantitative; Random; SerP; SerPl; SerPlas; Serum; Serum or plasma; SR; Substance concentration

Where you may see this code

You may see this code in lab systems, lab reports, EHR exports, interoperability feeds, or other structured clinical data exchanges.

Common synonyms

Frequently asked questions