LOINC Code 81879-9: t(11;22)(q24;q12.2)(FLI1,EWSR1) and t(21;22)(q22.3;q12.2)(ERG,EWSR1) fusion transcript Molgen Doc (Bld/Tiss)

What is this code?

LOINC codes identify tests, measurements, observations, survey items, and clinical questions in a standardized way. It is associated with the component t(11;22)(q24;q12.2)(FLI1,EWSR1) & t(21;22)(q22.3;q12.2)(ERG,EWSR1) fusion transcript. It is commonly used with the system or sample type Bld/Tiss.

When is it used?

• Used in lab systems, EHRs, and clinical data exchange.
• May identify a test, observation, survey item, or clinical document request rather than a diagnosis.
• Status: ACTIVE
• Order vs observation: Both
• Method: Molgen

What it does not mean

• The code identifies the observation or test, not the actual result.

Key facts

• t(11;22)(q24;q12.2)(FLI1,EWSR1) and t(21;22)(q22.3;q12.2)(ERG,EWSR1) fusion transcript in Blood or Tissue by Molecular genetics method
• t(11;22)(q24;q12.2)(FLI1,EWSR1) & t(21;22)(q22.3;q12.2)(ERG,EWSR1) fusion transcript
• Rearrangements of the EWSR1 gene at 22q12 with FLI1 at 11q24 or ERG at 21q22 collectively occur in about 95% of Ewing sarcoma (EWS) and primitive neuroectodermal tumors (PNET), both types of small round-cell tumors. The fusion transcripts can be detected by various methods, including reverse transcriptase PCR and FISH. A positive result is consistent with a diagnosis of EWS/PNET. A negative result does not rule out the presence of fusion transcripts that may be present, but below the detection limit of an assay.
• Blood; DNA; Document; Ewing sarcoma breakpoint region 1; Ewing sarcoma breakpoint region 2; EWS; EWSCR; EWSR1-FLI1 + EWSR1-ERG; EWSR2; Finding; Findings; Friend leukemia virus integration 1; gene fusion; gene translocation; Genetics; Heredity; Heritable; Inherited; Molecular genetics; Molecular pathology; MOLPATH; MOLPATH.TRANSLOCATION; PCR; Point in time; Random; RNA; SIC-1; T prime; t(11,22)(FLI1,EWSR1) gene translocation; t(11;22)(FLI1,EWSR1); t(21,22)(ERG,EWSR1) gene translocation; t(21;22)(ERG,EWSR1); Tissue; Tissue, unspecified; translocation; WB; Whole blood; Whole blood or Tissue

Where you may see this code

You may see this code in lab systems, lab reports, EHR exports, interoperability feeds, or other structured clinical data exchanges.

Common synonyms

Frequently asked questions