What does this LOINC code represent?

This LOINC code identifies a lab observation, measurement, question, or clinical concept in a standardized format.

Is this enough to understand my test result?

No. The code identifies the test or observation, but the interpretation depends on the actual result, reference range, and clinical context.

LOINCActiveBoth

LOINC Code 83052-1: PD-L1 by clone 22C3 Immune stain Ql (Tiss)

Name: LOINC Code 83052-1: PD-L1 by clone 22C3 Immune stain Ql (Tiss)
Creator: HealthAssure Clinical Team
Published: 2026-05-21T09:00:10.306Z

83052-1 is a LOINC code used to identify PD-L1 by clone 22C3 Immune stain Ql (Tiss) in laboratory and clinical observation data. You may see this code in lab systems, lab reports, EHR exports, interoperability feeds, or other structured clinical data exchanges. LOINC codes identify tests, measurements, observations, survey items, and clinical questions in a standardized way. It is associated with the component Programmed cell death ligand 1 by clone 22C3. It is commonly used with the system or sample type Tiss.

Reviewed by HealthAssure Clinical TeamUpdated 21 May 2026

What is this code?

LOINC codes identify tests, measurements, observations, survey items, and clinical questions in a standardized way. It is associated with the component Programmed cell death ligand 1 by clone 22C3. It is commonly used with the system or sample type Tiss.

When is it used?

Used in lab systems, EHRs, and clinical data exchange.
May identify a test, observation, survey item, or clinical document request rather than a diagnosis.
Status: ACTIVE
Order vs observation: Both
Method: Immune stain

What it does not mean

The code identifies the observation or test, not the actual result.

Key facts

PD-L1 by clone 22C3 [Presence] in Tissue by Immune stain

Programmed cell death ligand 1 by clone 22C3

This term should be used to report the presence of PD-L1 (CD274) protein expression in tumor cells as determined by immune staining with anti-PD-L1 clone 22C3. Patients with certain cancers, such as non-small cell lung cancer (NSCLC), whose tumors are positive for PD-L1 by 22C3 are eligible for anti-programmed death 1 (PD-1) receptor antibody therapy with pembrolizumab, which effectively prevents the binding of PD-L1 to PD-1. The percentage of viable tumor cells that show partial or complete PD-L1 membrane staining is reported using [LOINC83053-9]. A tumor with <50% staining by 22C3 is considered PD-L1 negative, and >= 50% is considered PD-L1 positive. This term was created for, but is not limited in use to, the Dako PD-L1 22C3 pharmDx test kit, which, as of November 2016, is FDA-approved as a companion diagnostic to assess whether patients with specific cancers are eligible for pembrolizumab therapy.

B7 homolog 1; B7-H1; CD274; Cluster of differentiation 274; i; IHC; Imm; Immunohistochemical stain; Immunostain; ImStn; Imun; Imune; Ordinal; PATHOLOGY; PDL1; PD-L1; PD-L1 by 22C3; Point in time; PR; QL; Qual; Qualitative; Random; Screen; St; Stains; Stn; Tissue; Tissue, unspecified

Where you may see this code

You may see this code in lab systems, lab reports, EHR exports, interoperability feeds, or other structured clinical data exchanges.

Common synonyms

PD-L1 by clone 22C3 Immune stain Ql (Tiss)PD-L1 by clone 22C3 [Presence] in Tissue by Immune stainPD-L1 by 22C3 Tiss Ql ImStnProgrammed cell death ligand 1 by clone 22C3PATHPD-L1 by clone 22C3, TissuePrThr

Frequently asked questions

Code details

Code83052-1

SystemLOINC

Display namePD-L1 by clone 22C3 Immune stain Ql (Tiss)

DescriptionProgrammed cell death ligand 1 by clone 22C3

Short namePD-L1 by 22C3 Tiss Ql ImStn

ComponentProgrammed cell death ligand 1 by clone 22C3

PropertyPrThr

TimingPt

System (specimen)Tiss

ScaleOrd

MethodImmune stain

ClassPATH

StatusACTIVE

Order/ObservationBoth

Flags

BillableNo

Valid clinical useNo

Source

SourceLOINC

Version2.82

Releasemain

First released2.58

Last changed2.73

Consumer names

PD-L1 by clone 22C3, Tissue

Part names

Programmed cell death ligand 1 by clone 22C3PrThrPtTissOrdImmune stainPD-L1 by clone 22C3Presence or ThresholdPoint in time (spot)Tissue and Smears

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from LOINC. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.