LOINC Code 97503-7: Abnormal Prion Protein Ql (CSF)

What is this code?

LOINC codes identify tests, measurements, observations, survey items, and clinical questions in a standardized way. It is associated with the component Prion protein.abnormal. It is commonly used with the system or sample type CSF.

When is it used?

• Used in lab systems, EHRs, and clinical data exchange.
• May identify a test, observation, survey item, or clinical document request rather than a diagnosis.
• Status: ACTIVE
• Order vs observation: Both

What it does not mean

• The code identifies the observation or test, not the actual result.

Key facts

• Abnormal Prion Protein [Presence] in Cerebral spinal fluid
• Prion protein.abnormal
• Detection of pathologic prions in cerebrospinal fluid (CSF). The submitter's test uses recombinant prion protein (PrP) as a reagent substrate and patient CSF in a real-time quaking-induced conversion (RT-QuIC) assay. If pathologic prions are present in the patient's CSF, they propagate misfolding of the reagent PrP to form amyloid, which is detected using a fluorescent indicator. RT-QuIC has been adopted in clinical practice due to the sensitivity, specificity, and use of CSF (not a brain biopsy) for testing. The submitter's reported sensitivity of RT-QuIC in detecting CJD is >90%, and the specificity approaches 100%.
• abn; Abn Prion Prot; abnorm; Bovine spongiform encephalopathy; BSE; Cerebral spinal fluid; Cerebrospinal Fl; ID; Infectious Disease; InfectiousDisease; Microbiology; Neuro; Neurology; Ordinal; Point in time; PR; Prot; PrP; QL; Qual; Qualitative; Random; Scrapie; Screen; Spinal Fl; Spinal Fld; Spinal Flu; Spinal Fluid

Where you may see this code

You may see this code in lab systems, lab reports, EHR exports, interoperability feeds, or other structured clinical data exchanges.

Common synonyms

Frequently asked questions