ICD10BillableValid for clinical use
ICD-10 Code A81.2: Progressive multifocal leukoencephalopathy
Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026
What is this code?
ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Certain infectious and parasitic diseases (A00-B99).
When is it used?
- May be used when a clinician documents progressive multifocal leukoencephalopathy in a patient's medical record.
- May appear in hospital records, claims, referrals, and clinical documentation.
- This code can be used as a clinically usable diagnosis entry in standardized coding workflows.
What it does not mean
- A code alone does not explain severity, treatment plan, or outcome.
- A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
Code hierarchy
chapter
1Certain infectious and parasitic diseases (A00-B99)
block
A80-A89Viral and prion infections of the central nervous system
category
A81Atypical virus infections of central nervous system
currentA81
Official coding notes
Inclusion terms
- Multifocal leukoencephalopathy NOS
Where you may see this code
You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.
Related specialists
Infectious Disease SpecialistGeneral Physician
Related codes
Sibling codes
Coverage-related procedures and services
CPT 70460high
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Source: CMS coverage guidance
CPT 70450high
COMPUTED TOMOGRAPHY, HEAD OR BRAIN; WITHOUT CONTRAST MATERIAL
Source: CMS coverage guidance
CPT 70470high
COMPUTED TOMOGRAPHY, HEAD OR BRAIN; WITHOUT CONTRAST MATERIAL, FOLLOWED BY CONTRAST MATERIAL(S) AND FURTHER SECTIONS
Source: CMS coverage guidance
CPT 72126high
COMPUTED TOMOGRAPHY, CERVICAL SPINE; WITH CONTRAST MATERIAL
Source: CMS coverage guidance
CPT 72125high
COMPUTED TOMOGRAPHY, CERVICAL SPINE; WITHOUT CONTRAST MATERIAL
Source: CMS coverage guidance
CPT 72127high
COMPUTED TOMOGRAPHY, CERVICAL SPINE; WITHOUT CONTRAST MATERIAL, FOLLOWED BY CONTRAST MATERIAL(S) AND FURTHER SECTIONS
Source: CMS coverage guidance
Mapped diagnoses and classifications
SNOMED_CT 192819000high
Cerebral degeneration due to progressive multifocal leukoencephalopathy
Source: SNOMED International ICD-10 map
SNOMED_CT 733193001high
Dementia with progressive multifocal leukoencephalopathy
Source: SNOMED International ICD-10 map
SNOMED_CT 713487008high
Progressive multifocal leucoencephalopathy co-occurrent with human immunodeficiency virus infection
Source: SNOMED International ICD-10 map
SNOMED_CT 22255007high
Progressive multifocal leukoencephalopathy
Source: SNOMED International ICD-10 map
SNOMED_CT 420554003high
Progressive multifocal leucoencephalopathy with AIDS (acquired immunodeficiency syndrome)
Source: SNOMED International ICD-10 map
Coding guidelines
Compatibility
Legacy and official ICD code match exactly.
Legacy codes
A81.2
Common synonyms
Progressive multifocal leukoencephalopathy
Frequently asked questions
About this content
This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.