ICD10
ICD-10 Code B25: Cytomegaloviral disease
Reviewed by HealthAssure Clinical TeamUpdated 21 May 2026
What is this code?
ICD-10 entries help standardize how diagnoses are organized for coding, reporting, analytics, and documentation. This code sits within the broader ICD-10 area for Certain infectious and parasitic diseases (A00-B99).
đź“‹Clinical overview
This ICD-10 code is commonly used when documentation describes cytomegaloviral disease. The most accurate code depends on whether the chart identifies pneumonitis, hepatitis, pancreatitis, another specified CMV manifestation, or an unspecified cytomegaloviral presentation.
When is it used?
- May be used when a clinician documents cytomegaloviral disease in a patient's medical record.
- May appear in hospital records, claims, referrals, and clinical documentation.
- This code may act more like a grouping or parent code, so a more specific child code may be used in final documentation when available.
What it does not mean
- A code alone does not explain severity, treatment plan, or outcome.
- A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
- This entry may represent a broader category rather than the most specific billable code.
đź©şClinical context
When commonly used
- Infectious-disease, transplant, oncology, inpatient, pulmonary, gastroenterology, and follow-up documentation where CMV is part of the active assessment, especially in immunocompromised patients.
- Coding and utilization-review workflows where the chart identifies the affected organ system and that organ involvement changes final CMV code specificity.
Common management context
- Evaluation often includes viral-testing review, symptom assessment, organ-specific monitoring, imaging or lab review, antiviral-treatment planning, and specialist coordination when CMV causes clinically significant disease.
- Documentation usually becomes more specific when the chart identifies lung versus liver versus pancreatic involvement, or names another specified CMV manifestation rather than leaving the disease broad or unspecified.
- Specialist context already linked on this page includes Infectious Disease Specialist, General Physician.
🔍Key distinctions
Important notes
- This ICD-10 family captures clinically significant cytomegaloviral disease across multiple organ systems rather than a single anatomic site alone.
- Organ-system detail matters here, because pneumonitis, hepatitis, pancreatitis, and other specified CMV manifestations are coded separately when documented.
- This parent page groups cytomegaloviral disease across organ-system patterns, so the final billable code usually depends on whether the chart identifies pneumonitis, hepatitis, pancreatitis, another specified CMV manifestation, or an unspecified cytomegaloviral presentation.
- Documentation that describes cytomegaloviral disease is coded differently from herpes simplex infection, other viral hepatitis, bacterial pneumonia, or noninfectious organ inflammation because the CMV organism and affected organ system drive final code selection.
Important exclusions
- congenital cytomegalovirus infection (P35.1)
- cytomegaloviral mononucleosis (B27.1-)
Related codes to consider
B25.0Cytomegaloviral pneumonitis
Related cytomegaloviral-disease ICD-10 code; documentation often becomes more specific when the chart identifies lung versus liver versus pancreatic involvement or another named CMV manifestation.
B25.1Cytomegaloviral hepatitis
Related cytomegaloviral-disease ICD-10 code; documentation often becomes more specific when the chart identifies lung versus liver versus pancreatic involvement or another named CMV manifestation.
B25.2Cytomegaloviral pancreatitis
Related cytomegaloviral-disease ICD-10 code; documentation often becomes more specific when the chart identifies lung versus liver versus pancreatic involvement or another named CMV manifestation.
B25.8Other cytomegaloviral diseases
Related cytomegaloviral-disease ICD-10 code; documentation often becomes more specific when the chart identifies lung versus liver versus pancreatic involvement or another named CMV manifestation.
Code hierarchy
chapter
1Certain infectious and parasitic diseases (A00-B99)
block
B25-B34Other viral diseases
currentB25-B34
Official coding notes
Excludes1 (do not code together)
- congenital cytomegalovirus infection (P35.1)
- cytomegaloviral mononucleosis (B27.1-)
Where you may see this code
You may see this entry in coding references, medical records, or claims workflows when a broader diagnosis category is being reviewed before a more specific code is chosen.
Related specialists
Infectious Disease SpecialistGeneral Physician
Related codes
Sibling codes
Coding guidelines
Compatibility
Legacy code aligns to an official FY 2026 category. Frontend should resolve to the official category page and surface the billable child codes.
Legacy codes
B25
Replacement codes
B25.0 — Cytomegaloviral pneumonitisB25.1 — Cytomegaloviral hepatitisB25.2 — Cytomegaloviral pancreatitisB25.8 — Other cytomegaloviral diseasesB25.9 — Cytomegaloviral disease, unspecified
Common synonyms
Cytomegaloviral disease
Frequently asked questions
About this content
This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.