ICD10
ICD-10 Code C49: Malignant neoplasm of other connective and soft tissue
Reviewed by HealthAssure Clinical TeamUpdated 21 May 2026
What is this code?
ICD-10 entries help standardize how diagnoses are organized for coding, reporting, analytics, and documentation. This code sits within the broader ICD-10 area for Neoplasms (C00-D49).
When is it used?
- May be used when a clinician documents malignant neoplasm of other connective and soft tissue in a patient's medical record.
- May appear in hospital records, claims, referrals, and clinical documentation.
- This code may act more like a grouping or parent code, so a more specific child code may be used in final documentation when available.
What it does not mean
- A code alone does not explain severity, treatment plan, or outcome.
- A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
- This entry may represent a broader category rather than the most specific billable code.
Code hierarchy
chapter
2Neoplasms (C00-D49)
block
C00-C96Malignant neoplasms
block
C00-C75Malignant neoplasms, stated or presumed to be primary (of specified sites), and certain specified histologies, except neuroendocrine, and of lymphoid, hematopoietic and related tissue
block
C45-C49Malignant neoplasms of mesothelial and soft tissue
currentC45-C49
Official coding notes
Includes
- malignant neoplasm of blood vessel
- malignant neoplasm of bursa
- malignant neoplasm of cartilage
- malignant neoplasm of fascia
- malignant neoplasm of fat
- malignant neoplasm of ligament, except uterine
- malignant neoplasm of lymphatic vessel
- malignant neoplasm of muscle
- malignant neoplasm of synovia
- malignant neoplasm of tendon (sheath)
Excludes1 (do not code together)
- malignant neoplasm of cartilage (of):
- articular (C40-C41)
- larynx (C32.3)
- nose (C30.0)
- malignant neoplasm of connective tissue of breast (C50.-)
Excludes2 (may code together if documented)
- Kaposi's sarcoma of soft tissue (C46.1)
- malignant neoplasm of heart (C38.0)
- malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
- malignant neoplasm of peritoneum (C48.2)
- malignant neoplasm of retroperitoneum (C48.0)
- malignant neoplasm of uterine ligament (C57.3)
- mesothelioma (C45.-)
Where you may see this code
You may see this entry in coding references, medical records, or claims workflows when a broader diagnosis category is being reviewed before a more specific code is chosen.
Related specialists
OncologistGeneral Physician
Related codes
C49.0Malignant neoplasm of connective and soft tissue of head, face and neckcodeC49.3Malignant neoplasm of connective and soft tissue of thoraxcodeC49.4Malignant neoplasm of connective and soft tissue of abdomencodeC49.5Malignant neoplasm of connective and soft tissue of pelviscodeC49.6Malignant neoplasm of connective and soft tissue of trunk, unspecifiedcodeC49.8Malignant neoplasm of overlapping sites of connective and soft tissuecodeC49.9Malignant neoplasm of connective and soft tissue, unspecifiedcode
Sibling codes
Coding guidelines
Compatibility
Legacy code aligns to an official FY 2026 category. Frontend should resolve to the official category page and surface the billable child codes.
Legacy codes
C49
Replacement codes
C49.0 — Malignant neoplasm of connective and soft tissue of head, face and neckC49.3 — Malignant neoplasm of connective and soft tissue of thoraxC49.4 — Malignant neoplasm of connective and soft tissue of abdomenC49.5 — Malignant neoplasm of connective and soft tissue of pelvisC49.6 — Malignant neoplasm of connective and soft tissue of trunk, unspecifiedC49.8 — Malignant neoplasm of overlapping sites of connective and soft tissueC49.9 — Malignant neoplasm of connective and soft tissue, unspecified
Common synonyms
Malignant neoplasm of other connective and soft tissue
Frequently asked questions
About this content
This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.