ICD10BillableValid for clinical use
ICD-10 Code D49.6: Neoplasm of unspecified behavior of brain
Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026
What is this code?
ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Neoplasms (C00-D49).
When is it used?
- May be used when a clinician documents neoplasm of unspecified behavior of brain in a patient's medical record.
- May appear in hospital records, claims, referrals, and clinical documentation.
- This code can be used as a clinically usable diagnosis entry in standardized coding workflows.
What it does not mean
- A code alone does not explain severity, treatment plan, or outcome.
- A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
Code hierarchy
chapter
2Neoplasms (C00-D49)
block
D49Neoplasms of unspecified behavior (D49)
category
D49Neoplasms of unspecified behavior
currentD49
Official coding notes
Excludes1 (do not code together)
- neoplasm of unspecified behavior of cerebral meninges (D49.7)
- neoplasm of unspecified behavior of cranial nerves (D49.7)
Where you may see this code
You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.
Related specialists
OncologistGeneral PhysicianNeurologist
Related codes
D49Neoplasms of unspecified behaviorcategoryD49.0Neoplasm of unspecified behavior of digestive systemcodeD49.1Neoplasm of unspecified behavior of respiratory systemcodeD49.2Neoplasm of unspecified behavior of bone, soft tissue, and skincodeD49.3Neoplasm of unspecified behavior of breastcodeD49.4Neoplasm of unspecified behavior of bladdercodeD49.5Neoplasm of unspecified behavior of other genitourinary organscategoryD49.7Neoplasm of unspecified behavior of endocrine glands and other parts of nervous systemcodeD49.8Neoplasm of unspecified behavior of other specified sitescategoryD49.9Neoplasm of unspecified behavior of unspecified sitecode
Sibling codes
D49Neoplasms of unspecified behaviorD49.0Neoplasm of unspecified behavior of digestive systembillableD49.1Neoplasm of unspecified behavior of respiratory systembillableD49.2Neoplasm of unspecified behavior of bone, soft tissue, and skinbillableD49.3Neoplasm of unspecified behavior of breastbillableD49.4Neoplasm of unspecified behavior of bladderbillableD49.5Neoplasm of unspecified behavior of other genitourinary organsD49.7Neoplasm of unspecified behavior of endocrine glands and other parts of nervous systembillableD49.8Neoplasm of unspecified behavior of other specified sitesD49.9Neoplasm of unspecified behavior of unspecified sitebillable
Coverage-related procedures and services
CPT 81540high
ONCOLOGY (TUMOR OF UNKNOWN ORIGIN), MRNA, GENE EXPRESSION PROFILING BY REAL-TIME RT-PCR OF 92 GENES (87 CONTENT AND 5 HOUSEKEEPING) TO CLASSIFY TUMOR INTO MAIN CANCER TYPE AND SUBTYPE, UTILIZING FORMALIN-FIXED PARAFFIN-EMBEDDED TISSUE, ALGORITHM REPORTED AS A PROBABILITY OF A PREDICTED MAIN CANCER TYPE AND SUBTYPE
Source: CMS coverage guidance
CPT 61800high
APPLICATION OF STEREOTACTIC HEADFRAME FOR STEREOTACTIC RADIOSURGERY (LIST SEPARATELY IN ADDITION TO CODE FOR PRIMARY PROCEDURE)
Source: CMS coverage guidance
CPT 70460high
COMPUTED TOMOGRAPHY, HEAD OR BRAIN; WITH CONTRAST MATERIAL(S)
Source: CMS coverage guidance
CPT 70450high
COMPUTED TOMOGRAPHY, HEAD OR BRAIN; WITHOUT CONTRAST MATERIAL
Source: CMS coverage guidance
CPT 70470high
COMPUTED TOMOGRAPHY, HEAD OR BRAIN; WITHOUT CONTRAST MATERIAL, FOLLOWED BY CONTRAST MATERIAL(S) AND FURTHER SECTIONS
Source: CMS coverage guidance
CPT 95940high
CONTINUOUS INTRAOPERATIVE NEUROPHYSIOLOGY MONITORING IN THE OPERATING ROOM, ONE ON ONE MONITORING REQUIRING PERSONAL ATTENDANCE, EACH 15 MINUTES (LIST SEPARATELY IN ADDITION TO CODE FOR PRIMARY PROCEDURE)
Source: CMS coverage guidance
Coding guidelines
Common synonyms
Neoplasm of unspecified behavior of brainNeoplasm of behavior of brain
Frequently asked questions
About this content
This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.