ICD10BillableValid for clinical use
ICD-10 Code G31.81: Alpers disease
Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026
What is this code?
ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Diseases of the nervous system (G00-G99).
When is it used?
- May be used when a clinician documents alpers disease in a patient's medical record.
- May appear in hospital records, claims, referrals, and clinical documentation.
- This code can be used as a clinically usable diagnosis entry in standardized coding workflows.
What it does not mean
- A code alone does not explain severity, treatment plan, or outcome.
- A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
Code hierarchy
chapter
6Diseases of the nervous system (G00-G99)
block
G30-G32Other degenerative diseases of the nervous system
category
G31Other degenerative diseases of nervous system, not elsewhere classified
category
G31.8Other specified degenerative diseases of nervous system
currentG31.8
Official coding notes
Inclusion terms
- Grey-matter degeneration
Where you may see this code
You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.
Related specialists
NeurologistGeneral Physician
Related codes
G31.80Leukodystrophy, unspecifiedcodeG31.82Leigh's diseasecodeG31.83Neurocognitive disorder with Lewy bodiescodeG31.84Mild cognitive impairment of uncertain or unknown etiologycodeG31.85Corticobasal degenerationcodeG31.86Alexander diseasecodeG31.87Primary progressive apraxia of speechcodeG31.89Other specified degenerative diseases of nervous systemcode
Sibling codes
G31.80Leukodystrophy, unspecifiedbillableG31.82Leigh's diseasebillableG31.83Neurocognitive disorder with Lewy bodiesbillableG31.84Mild cognitive impairment of uncertain or unknown etiologybillableG31.85Corticobasal degenerationbillableG31.86Alexander diseasebillableG31.87Primary progressive apraxia of speechbillableG31.89Other specified degenerative diseases of nervous systembillable
Coverage-related procedures and services
CPT 70460high
COMPUTED TOMOGRAPHY, HEAD OR BRAIN; WITH CONTRAST MATERIAL(S)
Source: CMS coverage guidance
CPT 70450high
COMPUTED TOMOGRAPHY, HEAD OR BRAIN; WITHOUT CONTRAST MATERIAL
Source: CMS coverage guidance
CPT 70470high
COMPUTED TOMOGRAPHY, HEAD OR BRAIN; WITHOUT CONTRAST MATERIAL, FOLLOWED BY CONTRAST MATERIAL(S) AND FURTHER SECTIONS
Source: CMS coverage guidance
CPT 72126high
COMPUTED TOMOGRAPHY, CERVICAL SPINE; WITH CONTRAST MATERIAL
Source: CMS coverage guidance
CPT 72125high
COMPUTED TOMOGRAPHY, CERVICAL SPINE; WITHOUT CONTRAST MATERIAL
Source: CMS coverage guidance
CPT 72127high
COMPUTED TOMOGRAPHY, CERVICAL SPINE; WITHOUT CONTRAST MATERIAL, FOLLOWED BY CONTRAST MATERIAL(S) AND FURTHER SECTIONS
Source: CMS coverage guidance
Coding guidelines
Common synonyms
Alpers disease
Frequently asked questions
About this content
This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.