ICD10BillableValid for clinical use
ICD-10 Code E74.4: Disorders of pyruvate metabolism and gluconeogenesis
Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026
What is this code?
ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Endocrine, nutritional and metabolic diseases (E00-E89).
When is it used?
- May be used when a clinician documents disorders of pyruvate metabolism and gluconeogenesis in a patient's medical record.
- May appear in hospital records, claims, referrals, and clinical documentation.
- This code can be used as a clinically usable diagnosis entry in standardized coding workflows.
What it does not mean
- A code alone does not explain severity, treatment plan, or outcome.
- A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
Code hierarchy
chapter
4Endocrine, nutritional and metabolic diseases (E00-E89)
block
E70-E88Metabolic disorders
category
E74Other disorders of carbohydrate metabolism
currentE74
Official coding notes
Inclusion terms
- Deficiency of phosphoenolpyruvate carboxykinase
- Deficiency of pyruvate carboxylase
- Deficiency of pyruvate dehydrogenase
Excludes1 (do not code together)
- disorders of pyruvate metabolism and gluconeogenesis with anemia (D55.-)
- Leigh's syndrome (G31.82)
Where you may see this code
You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.
Related specialists
EndocrinologistGeneral Physician
Related codes
E74.0Glycogen storage diseasecategoryE74.1Disorders of fructose metabolismcategoryE74.2Disorders of galactose metabolismcategoryE74.3Other disorders of intestinal carbohydrate absorptioncategoryE74.8Other specified disorders of carbohydrate metabolismcategoryE74.9Disorder of carbohydrate metabolism, unspecifiedcode
Sibling codes
Coverage-related procedures and services
CPT 93598high
CARDIAC OUTPUT MEASUREMENT(S), THERMODILUTION OR OTHER INDICATOR DILUTION METHOD, PERFORMED DURING CARDIAC CATHETERIZATION FOR THE EVALUATION OF CONGENITAL HEART DEFECTS (LIST SEPARATELY IN ADDITION TO CODE FOR PRIMARY PROCEDURE)
Source: CMS coverage guidance
CPT 93454high
CATHETER PLACEMENT IN CORONARY ARTERY(S) FOR CORONARY ANGIOGRAPHY, INCLUDING INTRAPROCEDURAL INJECTION(S) FOR CORONARY ANGIOGRAPHY, IMAGING SUPERVISION AND INTERPRETATION;
Source: CMS coverage guidance
CPT 93455high
CATHETER PLACEMENT IN CORONARY ARTERY(S) FOR CORONARY ANGIOGRAPHY, INCLUDING INTRAPROCEDURAL INJECTION(S) FOR CORONARY ANGIOGRAPHY, IMAGING SUPERVISION AND INTERPRETATION; WITH CATHETER PLACEMENT(S) IN BYPASS GRAFT(S) (INTERNAL MAMMARY, FREE ARTERIAL, VENOUS GRAFTS) INCLUDING INTRAPROCEDURAL INJECTION(S) FOR BYPASS GRAFT ANGIOGRAPHY
Source: CMS coverage guidance
CPT 93457high
CATHETER PLACEMENT IN CORONARY ARTERY(S) FOR CORONARY ANGIOGRAPHY, INCLUDING INTRAPROCEDURAL INJECTION(S) FOR CORONARY ANGIOGRAPHY, IMAGING SUPERVISION AND INTERPRETATION; WITH CATHETER PLACEMENT(S) IN BYPASS GRAFT(S) (INTERNAL MAMMARY, FREE ARTERIAL, VENOUS GRAFTS) INCLUDING INTRAPROCEDURAL INJECTION(S) FOR BYPASS GRAFT ANGIOGRAPHY AND RIGHT HEART CATHETERIZATION
Source: CMS coverage guidance
CPT 93458high
CATHETER PLACEMENT IN CORONARY ARTERY(S) FOR CORONARY ANGIOGRAPHY, INCLUDING INTRAPROCEDURAL INJECTION(S) FOR CORONARY ANGIOGRAPHY, IMAGING SUPERVISION AND INTERPRETATION; WITH LEFT HEART CATHETERIZATION INCLUDING INTRAPROCEDURAL INJECTION(S) FOR LEFT VENTRICULOGRAPHY, WHEN PERFORMED
Source: CMS coverage guidance
CPT 93459high
CATHETER PLACEMENT IN CORONARY ARTERY(S) FOR CORONARY ANGIOGRAPHY, INCLUDING INTRAPROCEDURAL INJECTION(S) FOR CORONARY ANGIOGRAPHY, IMAGING SUPERVISION AND INTERPRETATION; WITH LEFT HEART CATHETERIZATION INCLUDING INTRAPROCEDURAL INJECTION(S) FOR LEFT VENTRICULOGRAPHY, WHEN PERFORMED, CATHETER PLACEMENT(S) IN BYPASS GRAFT(S) (INTERNAL MAMMARY, FREE ARTERIAL, VENOUS GRAFTS) WITH BYPASS GRAFT ANGIOGRAPHY
Source: CMS coverage guidance
Mapped diagnoses and classifications
SNOMED_CT 237993009high
Combined complex deficiencies
Source: SNOMED International ICD-10 map
SNOMED_CT 124116001high
Deficiency of D-lactate dehydrogenase
Source: SNOMED International ICD-10 map
SNOMED_CT 124115002high
Deficiency of L-lactate dehydrogenase
Source: SNOMED International ICD-10 map
SNOMED_CT 124141008high
Deficiency of L-lactate dehydrogenase (cytochrome)
Source: SNOMED International ICD-10 map
SNOMED_CT 124185005high
Deficiency of NADPH-ferrihemoprotein reductase
Source: SNOMED International ICD-10 map
SNOMED_CT 124186006high
Deficiency of NAPH cytochrome-c>2< reductase
Source: SNOMED International ICD-10 map
Coding guidelines
Compatibility
Legacy and official ICD code match exactly.
Legacy codes
E74.4
Common synonyms
Disorders of pyruvate metabolism and gluconeogenesis
Frequently asked questions
About this content
This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.