ICD10BillableValid for clinical use
ICD-10 Code E85.4: Organ-limited amyloidosis
Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026
What is this code?
ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Endocrine, nutritional and metabolic diseases (E00-E89).
When is it used?
- May be used when a clinician documents organ-limited amyloidosis in a patient's medical record.
- May appear in hospital records, claims, referrals, and clinical documentation.
- This code can be used as a clinically usable diagnosis entry in standardized coding workflows.
What it does not mean
- A code alone does not explain severity, treatment plan, or outcome.
- A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
Code hierarchy
chapter
4Endocrine, nutritional and metabolic diseases (E00-E89)
block
E70-E88Metabolic disorders
category
E85Amyloidosis
currentE85
Official coding notes
Inclusion terms
- Localized amyloidosis
- Transthyretin-related (ATTR) familial amyloid cardiomyopathy
Where you may see this code
You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.
Related specialists
EndocrinologistGeneral Physician
Related codes
Sibling codes
Coverage-related procedures and services
CPT 11720high
DEBRIDEMENT OF NAIL(S) BY ANY METHOD(S); 1 TO 5
Source: CMS coverage guidance
CPT 11721high
DEBRIDEMENT OF NAIL(S) BY ANY METHOD(S); 6 OR MORE
Source: CMS coverage guidance
HCPCS G0127high
TRIMMING OF DYSTROPHIC NAILS, ANY NUMBER
Source: CMS coverage guidance
CPT 11719high
TRIMMING OF NONDYSTROPHIC NAILS, ANY NUMBER
Source: CMS coverage guidance
CPT 81404high
MOLECULAR PATHOLOGY PROCEDURE, LEVEL 5 (EG, ANALYSIS OF 2-5 EXONS BY DNA SEQUENCE ANALYSIS, MUTATION SCANNING OR DUPLICATION/DELETION VARIANTS OF 6-10 EXONS, OR CHARACTERIZATION OF A DYNAMIC MUTATION DISORDER/TRIPLET REPEAT BY SOUTHERN BLOT ANALYSIS) UGT1A1 (UDP GLUCURONOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1) (EG, HEREDITARY UNCONJUGATED HYPERBILIRUBINEMIA [CRIGLER-NAJJAR SYNDROME]) FULL GENE SEQUENCE
Source: CMS coverage guidance
CPT 11056high
PARING OR CUTTING OF BENIGN HYPERKERATOTIC LESION (EG, CORN OR CALLUS); 2 TO 4 LESIONS
Source: CMS coverage guidance
Mapped diagnoses and classifications
SNOMED_CT 425879009high
AA amyloid nephropathy
Source: SNOMED International ICD-10 map
SNOMED_CT 783161005high
ABri amyloidosis
Source: SNOMED International ICD-10 map
SNOMED_CT 783258000high
ADan amyloidosis
Source: SNOMED International ICD-10 map
SNOMED_CT 417939004high
Amyloid corneal degeneration
Source: SNOMED International ICD-10 map
SNOMED_CT 282357008high
Amyloid of ureter
Source: SNOMED International ICD-10 map
SNOMED_CT 232076001high
Amyloid of vitreous
Source: SNOMED International ICD-10 map
Coding guidelines
Compatibility
Legacy and official ICD code match exactly.
Legacy codes
E85.4
Common synonyms
Organ-limited amyloidosis
Frequently asked questions
About this content
This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.