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ICD-10 Code E88.3: Tumor lysis syndrome

E88.3 is a billable ICD-10 diagnosis code used to classify Tumor lysis syndrome in medical records and claims. You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records. ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Endocrine, nutritional and metabolic diseases (E00-E89).

What is this code?

ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Endocrine, nutritional and metabolic diseases (E00-E89).

When is it used?

  • May be used when a clinician documents tumor lysis syndrome in a patient's medical record.
  • May appear in hospital records, claims, referrals, and clinical documentation.
  • This code can be used as a clinically usable diagnosis entry in standardized coding workflows.

What it does not mean

  • A code alone does not explain severity, treatment plan, or outcome.
  • A medical code should not be treated as a substitute for a doctor's diagnosis or advice.

Code hierarchy

chapter
4Endocrine, nutritional and metabolic diseases (E00-E89)
block
E70-E88Metabolic disorders
category
E88Other and unspecified metabolic disorders
currentE88

Official coding notes

Inclusion terms
  • Tumor lysis syndrome (spontaneous)
  • Tumor lysis syndrome following antineoplastic drug chemotherapy
Applicable to
  • code for adverse effect, if applicable, to identify drug (T45.1X5)
Use additional code
  • code for adverse effect, if applicable, to identify drug (T45.1X5)

Where you may see this code

You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.

Related specialists

EndocrinologistGeneral PhysicianOncologist

Coverage-related procedures and services

CPT 94642high
AEROSOL INHALATION OF PENTAMIDINE FOR PNEUMOCYSTIS CARINII PNEUMONIA TREATMENT OR PROPHYLAXIS
Source: CMS coverage guidance
CPT 94728high
AIRWAY RESISTANCE BY OSCILLOMETRY
Source: CMS coverage guidance
CPT 94450high
BREATHING RESPONSE TO HYPOXIA (HYPOXIA RESPONSE CURVE)
Source: CMS coverage guidance
CPT 94060high
BRONCHODILATION RESPONSIVENESS, SPIROMETRY AS IN 94010, PRE- AND POST-BRONCHODILATOR ADMINISTRATION
Source: CMS coverage guidance
CPT 94070high
BRONCHOSPASM PROVOCATION EVALUATION, MULTIPLE SPIROMETRIC DETERMINATIONS AS IN 94010, WITH ADMINISTERED AGENTS (EG, ANTIGEN[S], COLD AIR, METHACHOLINE)
Source: CMS coverage guidance
CPT 94621high
CARDIOPULMONARY EXERCISE TESTING, INCLUDING MEASUREMENTS OF MINUTE VENTILATION, CO2 PRODUCTION, O2 UPTAKE, AND ELECTROCARDIOGRAPHIC RECORDINGS
Source: CMS coverage guidance

Coding guidelines

Compatibility

Legacy and official ICD code match exactly.
Legacy codes
E88.3

Common synonyms

Tumor lysis syndrome

Frequently asked questions

Code details

CodeE88.3
SystemICD10
Display nameTumor lysis syndrome
ChapterEndocrine, nutritional and metabolic diseases (E00-E89)
BlockMetabolic disorders

Flags

BillableYes
Valid clinical useYes

Source

SourceICD-10
Version2026-annual
Releaseannual
Year2026

Index terms

Matched terms
SyndromeTumor lysis syndrome(following antineoplastic chemotherapy) (spontaneous)NEC

About this content

This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.