ICD10BillableValid for clinical use
ICD-10 Code E78.2: Mixed hyperlipidemia
Reviewed by HealthAssure Clinical TeamUpdated 26 May 2026
What is this code?
ICD-10 codes are diagnosis classification codes used in healthcare records, reporting, coding workflows, and billing support. This code sits within the broader ICD-10 area for Endocrine, nutritional and metabolic diseases (E00-E89).
When is it used?
- May be used when a clinician documents mixed hyperlipidemia in a patient's medical record.
- May appear in hospital records, claims, referrals, and clinical documentation.
- This code can be used as a clinically usable diagnosis entry in standardized coding workflows.
What it does not mean
- A code alone does not explain severity, treatment plan, or outcome.
- A medical code should not be treated as a substitute for a doctor's diagnosis or advice.
Code hierarchy
chapter
4Endocrine, nutritional and metabolic diseases (E00-E89)
block
E70-E88Metabolic disorders
category
E78Disorders of lipoprotein metabolism and other lipidemias
currentE78
Official coding notes
Inclusion terms
- Broad- or floating-betalipoproteinemia
- Combined hyperlipidemia NOS
- Elevated cholesterol with elevated triglycerides NEC
- Fredrickson's hyperlipoproteinemia, type IIb or III
- Hyperbetalipoproteinemia with prebetalipoproteinemia
- Hypercholesteremia with endogenous hyperglyceridemia
- Hyperlipidemia, group C
- Tubo-eruptive xanthoma
- Xanthoma tuberosum
Excludes1 (do not code together)
- cerebrotendinous cholesterosis [van Bogaert-Scherer- Epstein] (E75.5)
- familial combined hyperlipidemia (E78.49)
Where you may see this code
You may see this code in hospital records, discharge summaries, insurance claims, encounter documentation, referrals, or other healthcare billing and coding records.
Related specialists
EndocrinologistGeneral Physician
Related codes
E78.0Pure hypercholesterolemiacategoryE78.1Pure hyperglyceridemiacodeE78.3HyperchylomicronemiacodeE78.4Other hyperlipidemiacategoryE78.5Hyperlipidemia, unspecifiedcodeE78.6Lipoprotein deficiencycodeE78.7Disorders of bile acid and cholesterol metabolismcategoryE78.8Other disorders of lipoprotein metabolismcategoryE78.9Disorder of lipoprotein metabolism, unspecifiedcode
Sibling codes
E78.0Pure hypercholesterolemiaE78.1Pure hyperglyceridemiabillableE78.3HyperchylomicronemiabillableE78.4Other hyperlipidemiaE78.5Hyperlipidemia, unspecifiedbillableE78.6Lipoprotein deficiencybillableE78.7Disorders of bile acid and cholesterol metabolismE78.8Other disorders of lipoprotein metabolismE78.9Disorder of lipoprotein metabolism, unspecifiedbillable
Coverage-related procedures and services
CPT 0349Uhigh
DRUG METABOLISM OR PROCESSING (MULTIPLE CONDITIONS), WHOLE BLOOD OR BUCCAL SPECIMEN, DNA ANALYSIS, 27 GENE REPORT, WITH VARIANT ANALYSIS, INCLUDING REPORTED PHENOTYPES AND IMPACTED GENE-DRUG INTERACTIONS
Source: CMS coverage guidance
CPT 0423Uhigh
PSYCHIATRY (EG, DEPRESSION, ANXIETY), GENOMIC ANALYSIS PANEL, INCLUDING VARIANT ANALYSIS OF 26 GENES, BUCCAL SWAB, REPORT INCLUDING METABOLIZER STATUS AND RISK OF DRUG TOXICITY BY CONDITION
Source: CMS coverage guidance
CPT 83090high
HOMOCYSTEINE
Source: CMS coverage guidance
CPT 83698high
LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2)
Source: CMS coverage guidance
CPT 82172high
APOLIPOPROTEIN, EACH
Source: CMS coverage guidance
CPT 86141high
C-REACTIVE PROTEIN; HIGH SENSITIVITY (HSCRP)
Source: CMS coverage guidance
Mapped diagnoses and classifications
SNOMED_CT 404163009high
Diffuse normolipemic plane xanthomatosis
Source: SNOMED International ICD-10 map
SNOMED_CT 238952003high
Eruptive xanthoma
Source: SNOMED International ICD-10 map
SNOMED_CT 398796005high
Familial type 3 hyperlipoproteinaemia
Source: SNOMED International ICD-10 map
SNOMED_CT 129591001high
Mixed hypercholesterolemia and hypertriglyceridemia
Source: SNOMED International ICD-10 map
SNOMED_CT 267434003high
Mixed hyperlipidaemia
Source: SNOMED International ICD-10 map
SNOMED_CT 238088006high
Primary combined hyperlipidaemia
Source: SNOMED International ICD-10 map
Coding guidelines
Compatibility
Legacy and official ICD code match exactly.
Legacy codes
E78.2
Common synonyms
Mixed hyperlipidemia
Frequently asked questions
About this content
This page is prepared by HealthAssure's clinical team using official coding standards from ICD-10. AI tools assist with drafting explanations, which are then reviewed and verified by healthcare professionals for accuracy. This content is for informational purposes and does not replace professional medical advice. Meet our team.